CAS: 149-30-4; Benzo[d]Thiazole-2(3H)-Thione

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2492-26-4 21303-50-4 54420-94-9

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CAS号95-16-9 苯并噻唑 | CAS号120-78-5 二硫化二苯并噻唑 | CAS号75-15-0 二硫化碳 | CAS号615-43-0 2-碘苯胺 | CAS号615-36-1 2-溴苯胺 | CAS号80082-65-1 氨曲南主环 | CAS号86299-47-0 头孢他啶侧链酸 | CAS号80756-85-0 头孢曲松杂质D | CAS号957-68-6 7-氨基头孢烷酸 | CAS号1074-18-6 2-(ethylamino)b... | CAS号10603-84-6 1,3-benzothiazo... | CAS号106296-65-5 5-(1,3-benzothi... | CAS号355-37-3 1H-全氟己烷 | CAS号120-78-5 二硫化二苯并噻唑 | CAS号55745-83-0 2-哌嗪-1-基-1,3-苯并噻唑 | CAS号4767-00-4 3-(2-苯并噻唑基硫代)丙酸 | CAS号91624-44-1 3(2H)-Benzothia... | CAS号107235-87-0 methyl 3-(benzo...

2-氯苯并噻唑置于copper(Ll) Sulfate Pentahydrate,1,2-乙二硫醇,Potassium Hydroxide体系中,用 水,二甲基亚砜 用作溶剂,化学反应 20.0H,以84%的收率获得2-巯基苯并噻唑
参考文献:铜(II)催化由芳基卤化物和1,2-乙二硫醇合成芳基硫醇
标题:铜(II)催化由芳基卤化物和1,2-乙二硫醇合成芳基硫醇
摘要:利用铜(II)催化剂和1,2-乙二硫醇开发了一种高效的过渡金属催化的从芳基卤化物单步合成芳基硫醇的方法.关键特征是使用现成的试剂,简单的操作以及相对温和的反应条件.该新协议显示了广泛的底物范围,具有出色的官能团相容性.由芳基卤化物直接以高收率制备各种芳基硫醇.此外,芳基硫醇原位用于合成更高级的分子,例如二芳基硫醚和苯并噻吩.
Doi:10.1002/adsc.201400941

专利信息

专利号:US-11708363-B2
优先权日:2020-09-30
标 题:Method for preparing a key intermediate for the synthesis of statins
发明人：CHEN FENER; CHENG DANG; LIU MINJIE; HUANG ZEDU; TAO YUAN; WANG JIAQI
权利人:UNIV FUDAN
摘要:Disclosed herein relates to organic synthesis, and more particularly to a method for preparing a key intermediate for the synthesis of statins. The key intermediate is 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylthio)methyl]-2,2-disubstituted-1,3-dioxan-4-yl] acetate of formula (I): n nwhere R 1 is a C 1 -C 8 alkyl group, a C 3 -C 8 cycloalkyl group, a monosubstituted or polysubstituted aryl group, or monosubstituted or polysubstituted aralkyl group; R 2 is hydrogen, or monosubstituted or polysubstituted C 1 -C 3 alkyl group, or halogen; and R 3 and R 4 are each independently a C 1 -C 5 alkyl group, a C 3 -C 7 cycloalkyl group, a C 3 -C 7 cycloalkenyl group, a C 1 -C 3 alkoxy group, a C 6 -C 10 aryl group, or C 7 -C 12 aralkyl group. In the method, a halomethyl compound and a thiol reagent are subjected to nucleophilic substitution in an organic solvent to synthesize a thioether, which then undergoes ketal exchange reaction with a carbonyl compound (V) in the presence of an organic acid to obtain a target product.

专利号:US-5919969-A
优先权日:1996-06-05
标 题 :Synthesis of yellow couplers
发明人：CRAWLEY MICHAEL W
权利人:EASTMAN KODAK CO
摘要:The invention provides a method of synthesis of a image-dye forming coupler of formula (I) wherein X is a substituent linked to the coupler by an atom of oxygen, sulfur or nitrogen R1 is an alkyl or aryl group, R2 is a hydrogen atom or an alkyl group; R3 to R7 are the same or different and selected from a hydrogen atom and substituent groups; which method comprises the reaction of a compound of formula (II) wherein R and R1 are the same or different and are as defined above for R1 and X is as defined above with a compound of formula (III) wherein R2 to R7 are as defined above, in the presence of an inert organic solvent.

专利号:US-6159673-A
优先权日:1996-07-17
标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.

专利号:US-9409945-B2
优先权日:1999-10-04
标 题 :Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
发明人：DESLONGCHAMPS PIERRE; DORY YVES; BERTHIAUME GILLES; OUELLET LUC; LAN RUOXI
权利人:OCERA THERAPEUTICS INC
摘要:A library of macrocyclic compounds of the formula (I) n n n n n n n n n n n n where part (A) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) y — bivalent radical or a covalent bond; n where part (B) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) z — bivalent radical, or a covalent bond; n where part (C) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) t — bivalent radical, or a covalent bond; and n where part (T) is a —Y-L-Z— radical wherein Y is CH 2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

专利号:US-2025101006-A1
优先权日:2022-01-31
标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents
发明人：BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÄNGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO
权利人:NOVARTIS AG
摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

专利号:EP-1473330-B1
优先权日:1996-07-17
标题:Process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.