二氯乙酰氯,1,8-辛二胺 反应生成N,N'-八亚甲基双二氯乙酰胺 参考文献:The Preparation And Biological Activity Of Some N,N'-Bis(Haloacyl)-Polymethylenediamines 标题:The Preparation And Biological Activity Of Some N,N'-Bis(Haloacyl)-Polymethylenediamines 摘要: Doi:10.1021/jm50016A002
专利号:US-10519108-B2 优先权日:2015-09-17 标 题:Inhibitors of retinaldehyde dehydrogenases and methods of use 发明人:SUMMERS JODY A; HARPER ANGELICA R; MATHER TIM; BURGETT ANTHONY; LE ANH THI QUYNH 权利人:UNIV OKLAHOMA; OKLAHOMA MED RES FOUND 摘要:Compounds having inhibitory activity against retinaldehyde dehydrogenases (RALDHs). The compounds can be used, for example, to inhibit synthesis of retinoic acid for the treatment of refractive error disorders such as myopia, and as infertility treatments by inhibiting spermatogenesis.
专利号:US-2006263340-A1 优先权日:2005-04-29 标题 :Treating gastrointestinal diseases with modulators of retinoic acid 发明人:ANDRIAN ULRICH H V; MORA RODRIGO 权利人:ANDRIAN ULRICH H V; MORA RODRIGO 摘要:T cells are programmed to target the gastrointestinal tract by activation with dendritic cells capable of producing and/or transporting retinoic acid. Methods for using the programmed dendritic cells and/or T and/or B cells to treat a variety of pathogens and infectious agents residing in the intestine are also disclosed. Similarly, inhibitors of retinoic acid synthesis by dendritic cells or other cells in the gut, and inhibitors of retinoic acid receptors in T and/or B cells or other cells in the intestinal mucosa, are disclosed for treating a variety of gastrointestinal autoimmune diseases such as inflammatory bowel disease and celiac disease.
专利号:TW-572896-B 优先权日:2000-05-26 标 题:Process for the synthesis of amine ethers from secondary amino oxides
专利号:JP-2001072642-A 优先权日:1999-08-05 标 题 :Method for producing dicarboxylic acid suitable for synthesis of polymer or polyamide
Haenisch M, Nguyen T, Fihn CA, Goldstein AS, Amory JK, Treuting P, Brabb T, Paik J. Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity. Int J Obes (Lond). 2021 Jul;45(7):1542-1552. doi: 10.1038/s41366-021-00818-1. Epub 2021 May 1.
合成参考文献
摘要:Toxicology and Applied Pharmacology., 2(715), 1960 [] 参考文献:10.1016/j.theriogenology.2003.07.026|10.1016/s0093-691x(03)00436-9 摘要:Munson L, Chassy LM, Asa C. Efficacy, safety and reversibility of bisdiamine as a male contraceptive in cats. Theriogenology. 2004 Jul;62(1-2):81–92. doi: 10.1016/j.theriogenology.2003.07.026.