CAS: 1370468-36-2; Dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-((S)-6-Phenyl-6H-Benzo[5,6][1,3]Oxazino[3,4-A]Indole-3,10-Diyl)Bis(1H-Imidazole-5,2-Diyl))Bis(Pyrrolidine-2,1-Diyl))Bis(3-Methyl-1-Oxobutane-2,1-Diyl))Dicarbamate

专利信息

专利号:US-9790207-B2
优先权日:2015-09-04
标题 :Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods
发明人：IVACHTCHENKO ALEXANDRE VASILIEVICH; MITKIN OLEG DMITRIEVICH
权利人:IVACHTCHENKO ALEXANDRE VASILIEVICH; IVASHCHENKO ANDREY ALEXANDROVICH; SAVCHUK NIKOLAY FILIPPOVICH; ALLA CHEM LLC
摘要:Compound represented by formula 1: n nor a pharmaceutically acceptable salt, a hydrate, a crystalline form, or a stereoisomer thereof, wherein:n nR1 is hydrogen, tert-butoxycarbonyl,n n nwhere R11 is an optionally substituted C 1 -C 6 alkyl, an optionally substituted C 3 -C 6 cycloalkyl, or an optionally substituted C 1 -C 6 alkyloxy, and arrows (â†?) indicate the position of substituents attachment;n nR2 is hydrogen, halogen, or C 1 -C 4 alkyl;n nR3 is an optionally substituted aryl, an optionally substituted aryloxy, an optionally substituted arylsulfanyl, an optionally substituted arylamino, or an optionally substituted nitrogen hetaryl;n n n n n n n n n n n n n where R41 is an optionally substituted C 1 -C 6 alkyl, an optionally substituted C 3 -C 6 cycloalkyl, or an optionally substituted C 1 -C 6 alkyloxy; X is buta-1,3-diynylene or 1,4-phenylene; arrows (â†?) indicate the position of substituents attacment.

专利号:US-12404246-B1
优先权日:2024-10-01
标 题:2-aminomethylimidazole mimics of NS4A and their effect thereof on hepatitis C virus NS3 protease
发明人：BARADWAN MOHAMMED A; OMAR ABDELSATTAR M; ELFAKY MAHMOUD A; EL-ARABY MOUSTAFA E; SOROR SAMEH H
权利人:BARADWAN MOHAMMED A; OMAR ABDELSATTAR M; ELFAKY MAHMOUD A; EL ARABY MOUSTAFA E; SOROR SAMEH H; UNIV KING ABDULAZIZ
摘要:Chronic hepatitis C is a global health problem affecting large number of people and leads to mortalities and morbidities. In this invention, new compounds belonging to 2-substituted-1H-imidazole-4-carboxamide derivatives (Formula I) intended for use in the treatment of hepatitis C are disclosed. The compounds interfere with the important viral peptide NS4A co-enzyme function. The described art includes chemical synthesis, spectral confirmation and binding assays with NS3 protein.

专利号:CN-107021968-A
优先权日:2017-05-25
标题:A method for the synthesis of indole compounds by oxidative dehydrogenation of indoline compounds catalyzed by multi-substituted BODIPY organic photocatalysts

专利号:CN-107021968-B
优先权日:2017-05-25
标题 :A method for the synthesis of indole compounds by oxidative dehydrogenation of indoline compounds catalyzed by multi-substituted BODIPY organic photocatalysts

专利号:EA-034084-B1
优先权日:2015-09-04
标 题:Pan-Genomic Protein Inhibitors of NS5A Hepatitis C Virus, Pharmaceutical Compositions, Intermediate Products for the Synthesis of Inhibitors and Methods for Their Production and Use

专利号:RU-2669919-C1
优先权日:2015-09-04
标题 :Pan-genomic inhibitors of the hepatitis c virus protein ns5a, pharmaceutical compositions, intermediates for the synthesis of inhibitors, and methods for their preparation and use