CAS: 1122-74-3; 4-Iodo-2-Methylsulfanylpyrimidine

相似化合物

1333077-61-4 2648368-66-3 107403-27-0

上下游产品

4-Chloro-2-methylthiopyrimidine 2-(methylsulfanyl)pyrimidine 2-(methylsulfanyl)pyrimidine 2-(methylthio)-4-(tributylstannyl)pyrimidine 2-(methylthio)-4-(trifluoromethyl)pyrimidine 4-iodo-6-methyl-2-methylsulfanyl-pyrimidine

📜2-甲硫基嘧啶置于四甲基乙二胺,Zinc(II) Chloride,碘体系中,用 四氢呋喃 用作溶剂,化学反应 2.0H,以77%的收率获得4-碘-2-甲基磺酰基嘧啶
参考文献:Azine And Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium-metal Combinations: Application To The Synthesis Of 5,9-Disubstituted Pyrido[3',2':4,5]Pyrrolo[1,2-C]Pyrimidines
标题:Azine And Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium-metal Combinations: Application To The Synthesis Of 5,9-Disubstituted Pyrido[3',2':4,5]Pyrrolo[1,2-C]Pyrimidines
摘要:The Synthesis Of Triaryl Methanols Was Investigated By Reacting Different 4-Metalated 2-Substituted Pyrimidines With Diaryl Ketones,The Latter Being Generated By Deprotocupration-Aroylation Of Azine And Diazine Substrates. Cyclization Of The Triaryl Methanols Thus Obtained Afforded Pyrido[3,2:4,5]Pyrrolo[1,2-C]Pyrimidines,Which Were Evaluated For Kinase Inhibition And Antiproliferative Activities In Melanoma Cells.
Doi:10.1055/s-0035-1560496

专利信息

专利号:US-6784190-B2
优先权日:1997-12-17
标 题 :Integrin receptor antagonists
发明人：ASKEW BEN C; COLEMAN PAUL J; DUGGAN MARK E; HALCZENKO WASYL; HARTMAN GEORGE D; HUNT CECILIA A; HUTCHINSON JOHN H; MEISSNER ROBERT S; PATANE MICHAEL A; SMITH GARRY R; WANG JIABING
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphavbeta3, alphavbeta5, and/or alphavbeta6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.