CAS: 89284-61-7; 4-Chloronicotinonitrile

该化合物是一种有机化合物,其特征为:4-Crolono-3-cyonpyridine,其特性为:4-Cyridine环,以氯原子取代4级,3级则以西诺组;该化合物一般为青黄色至浅褐色固体,因其芳香性特性而闻名;该化合物的分子配方反映其卤素和西洋子子子分体,有助于其在各种化学合成中的再活性和潜在应用;4-Chroloo-3-cyanopridine经常在制药工业中用作生物活性化合物合成的中间体,包括农用化学品和药品;其特性包括有机溶剂中的中溶性以及在标准条件下的稳定性,尽管由于氯和氰化物的功能的存在,应当加以谨慎处理,这可能会对健康造成风险;在实验室环境中与该化合物合作时,应当注意适当的安全措施.

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10177-29-4 114077-82-6 7418-70-4

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合成工艺路线路线简述

  • 合成目标产物 4-Chloro-3-Cyanopyridine 主要起始原料 4-Chloropyridine-3-Carboxamide
  • 100-54-9 = 89284-61-7
    反应条件:1.1 Reagents: Butyllithium,2,2,6,6-Tetramethylpiperidine Solvents: Tetrahydrofuran; -30 °C -> 0 °C; 15 Min,0 °C; 0 °C -> -80 °C1.2 Solvents: Tetrahydrofuran; 15 Min,-80 °C1.3 Reagents: Hexachloroethane; 15 Min,-80 °C; 30 Min,-80 °C; -80 °C -> Rt1.4 Reagents: Ammonium Chloride Solvents: Water
    标题:A New,Direct,And Efficient Synthesis Of Benzonaphthyridin-5-Ones
    作者:Cailly,Thomas; Fabis,Frederic; Rault,Sylvain
    参考文献:Tetrahedron 日期:2006 卷标:62(25) 页码:5862-5867]

    14906-64-0 = 89284-61-7 + 6602-54-6 + 33252-28-7
    反应条件:1.1 Reagents: Phosphorus Oxychloride
    标题:Site Selectivity In The Reaction Of 3-Substituted Pyridine 1-Oxides With Phosphoryl Chloride
    作者:Yamanaka,Hiroshi; Araki,Tomio; Sakamoto,Takao
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1988 卷标:36(6) 页码:2244-7]

    13939-06-5 + 166526-03-0 = 89284-61-7 + 1060802-59-6 + 100-54-9
    反应条件:1.1 Solvents: Acetonitrile,Water; 16 H,Ph 9.5,Rt -> 45 °C1.2 Reagents: Sodium Chloride Solvents: Ethanol; Overnight,-20 °C1.3 Reagents: Cesium Hydroxide Catalysts: Palladate(1-),[2′-(Amino-Kn)[1,1′-Biphenyl]-2-Yl-Kc]Chloro[2′-(Dicyclohexylphos... Solvents: 1-Methoxy-2-Propanol,Water; 15 H,80 °C
    标题:Palladium-Catalyzed Hydroxycarbonylation Of (Hetero)Aryl Halides For Dna-Encoded Chemical Library Synthesis
    作者:Li,Jian-Yuan; Miklossy,Gabriella; Modukuri,Ram K.; Bohren,Kurt M.; Yu,Zhifeng; Et Al
    参考文献:Bioconjugate Chemistry 日期:2019 卷标:30(8) 页码:2209-2215]

    6602-54-6 = 89284-61-7 + 827616-54-6
    反应条件:1.1 Reagents: Butyllithium,2,2,6,6-Tetramethylpiperidine Solvents: Tetrahydrofuran,Hexane; -30 °C; -30 °C -> 0 °C; 15 Min,0 °C; 0 °C -> -80 °C1.2 15 Min,-80 °C; 30 Min,-80 °C1.3 Reagents: Hexachloroethane Solvents: Tetrahydrofuran; 15 Min,-80 °C; 30 Min,-80 °C; -80 °C -> Rt1.4 Reagents: Ammonium Chloride Solvents: Water; Rt
    标题:Straightforward Access To Ethyl 3-Aminofuropyridine-2-Carboxylates From 1-Chloro-2-Cyano- Or 1-Hydroxy-2-Cyano-Substituted Pyridines
    作者:Cailly,Thomas; Lemaitre,Stephane; Fabis,Frederic; Rault,Sylvain
    参考文献:Synthesis 日期:2007 卷标:(20) 页码:3247-3251]

    100-54-9 = 89284-61-7 + 6602-54-6
    反应条件:1.1 Reagents: Butyllithium,2,2,6,6-Tetramethylpiperidine Solvents: Tetrahydrofuran; -30 °C; -30 °C -> 0 °C; 15 Min,0 °C; 0 °C -> -80 °C1.2 Solvents: Tetrahydrofuran; 15 Min,-80 °C; 30 Min,-80 °C1.3 Reagents: Hexachloroethane Solvents: Tetrahydrofuran; 15 Min,-80 °C; 30 Min,-80 °C; -80 °C -> Rt1.4 Reagents: Ammonium Chloride Solvents: Water; Rt
    标题:Synthesis Of Ortho-Substituted Cyanopyridines Through Lithio Intermediate Trapping
    作者:Cailly,Thomas; Fabis,Frederic; Lemaitre,Stephane; Bouillon,Alexandre; Rault,Sylvain
    参考文献:Tetrahedron Letters 日期:2005 卷标:46(1) 页码:135-137
📜3-氰基吡啶置于2,2,6,6-四甲基哌啶,正丁基锂,六氯乙烷体系中,用 四氢呋喃 作为反应溶剂,化学反应 0.75H,以37%的收率获得产物4-氯-3-氰基吡啶
参考文献:A New,Direct,And Efficient Synthesis Of Benzonaphthyridin-5-Ones
标题:A New,Direct,And Efficient Synthesis Of Benzonaphthyridin-5-Ones
摘要:Microwave-Assisted Suzuki Cross-Coupling Reaction Of 2-Fluorophenylboronic Acid With All Orthochlorocyanopyridine Isomers Allowed The Rapid Syntheses Of Key Intermediates For Anionic Ring Closure,Which Was Performed Using Potassium Hydroxide Under Microwave Irradiation To Give Benzonaphthyridin-5-Ones In High Yields. (C) 2006 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2006.04.030

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专利信息


专利号:CN-103626693-B
优先权日:2012-08-28
标题:A class of pleuromutilin derivatives, its pharmaceutical composition and its synthesis method and application

专利号:CN-103626693-A
优先权日:2012-08-28
标 题 :A class of pleuromutilin derivatives, its pharmaceutical composition and its synthesis method and application

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合成参考文献


参考文献:10.1055/s-2007-990810
摘要:Rault S, Cailly T, Lemaître S, Fabis F. Straightforward Access to Ethyl 3-Aminofuropyridine-2-carboxylates from 1-Chloro-2-cyano- or 1-Hydroxy-2-cyano-Substituted Pyridines. Synthesis. 2007 Oct;2007(20):3247–51. doi: 10.1055/s-2007-990810.
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