CAS: 6835-00-3; Hydroxystreptomycin

专利信息

专利号:US-11679182-B2
优先权日:2019-02-20
标题 :Methods of synthesis for a thioketal diol
发明人：HARRINGTON ROGER E; JACOBS JERBRENA C; DOYLE ROBERT
权利人:WARSAW ORTHOPEDIC INC
摘要:A method of making a hydroxyl-terminated thioketal diol is provided, the method comprising reacting a thioketal ester with a non-pyrophoric reducing agent to form a hydroxyl-terminated thioketal diol. The hydroxyl-terminated thioketal diol can be 2,2-(propane-2,2-diylbis(sulfanediyl)) diethanol. The non-pyrophoric reducing agent can be a sodium aluminum hydride, for example, sodium bis (2-methoxyethoxy)aluminum hydride. The thioketal ester can be dimethyl 2,2-(propane-2,2-diylbis(sulfanediyl)) diacetate. A biodegradable matrix prepared by reacting a hydroxyl-terminated thioketal diol with an isocyanate is provided. A method of making a biodegradable polyurethane composite is also provided.

专利号:US-5710032-A
优先权日:1991-09-18
标 题 :Secondary-metabolite biosynthesis genes from actinomycetes, method of isolating them and their use
发明人：PIEPERSBERG WOLFGANG; BRAEU BARBARA; SICHEL PETRA
权利人:HOECHST AG
摘要:Secondary-metabolite biosynthesis genes from actinomycetes, method of isolating them, and their use. The invention concerns secondary-metabolite biosynthesis genes from actinomycetes, a method of isolating secondary-metabolite and, in particular, 6-deoxy-sugar bio-synthesis genes, from actinomycetes using the gene probes strD, strE, strL and strM gene probes from Streptomyces griseus DSM40236, and structurally related genes, as gene probes for detecting the genes snot (coding for amphotheronolide B-dTDP-D-mycosaminyl transferase), snoD (coding for dTDP-D-glucose synthase) and snoM (coding for dTDP-4-keto-6-deoxy-D-glucose isomerase), or one or more secondary-metabolite biosynthesis genes from actinomycetes. The invention also concerns the use of secondary-metabolite biosynthesis genes thus isolated.

专利号:WO-9636643-A1
优先权日:1995-05-17
标 题 :Method of inhibiting restenosis using calreticulin
发明人：MICHALAK MAREK; LUCAS ALEXANDRA
权利人:UNIV ALBERTA
摘要:This invention relates to calreticulin, segments and derivatives thereof and to therapeutic compositions containing such products for treating restenosis. It relates also to methods of producing the products by chemical synthesis or employing recombinant techniques. The invention is also concerned with the use of the products for treating patients to prevent atherosclerosis development as well as recurrent plaque growth. A method of treating a patient to inhibit restenosis comprises administering to such patient in an amount which is effective to inhibit restenosis a compound selected from the group consisting of calreticulin; the C-domain of calreticulin; a C-domain containing segment of calreticulin; and a polypeptide which contains from about 6 to 100 amino acid residues and is an addition, substitution or deletion analog of the C-domain of calreticulin having the same functional activity. In a specific embodiment, the polypeptide has the amino acid sequence KEEEEKKRKEEEEAEEDEEDKDDKEDEDEDEEDKDEEEEE.

专利号:US-2025082601-A1
优先权日:2023-09-08
标题:Significantly non-toxic novel Cobalt(III) Schiff base complex induces apoptosis via G2-M cell cycle arrest in human breast cancer cell line MCF-7 and cell cycle arrest of colon cancer cell lines HCT-116 and SW- 480 via G0-G1
发明人：DASGUPTA SANCHARI; KAR KANISHA PAL; BARUA ATISH; GHOSH DIYA; KABI BIKASH; DEWAN KOUSHIK; CHANDRA ARPITA; BHAR SUNANDITA; DAS TANIMA
权利人:CHITTARANJAN NAT CANCER INSTITUTE
摘要:A significantly non-toxic novel mononuclear cobalt(III)-Schiff base complex (1) capable to induce apoptosis via G2-M cell cycle arrest in human breast cancer cell line MCF-7 and cell cycle arrest of colon cancer cell lines HCT-116 and SW-480 via G0-G1. The Schiff base complex (1) having >99% purity has been synthesized by a facile “One potâ€? synthesis method and has been characterized with standard spectroscopic techniques. Complex 1 exhibits cytotoxicity (IC50=16.81±1.33 μM) at much lower concentration in comparison to oxaliplatin (IC50=31.4±0.69 μM) against MCF-7 cells and causes apoptosis in colon cancer cell lines HCT-116 and SW-480 by arresting the cell cycle at the G0-G1 phase having IC50 values of 15.27±1.18 μM and 10.04±1.98 μM respectively comparable with the IC50 values of oxaliplatin which are 16.73±1.78 μM and 7.87±1.54 μM respectively after 24 h of treatment without being overly toxic to human PBMCs (IC50=>60 μM). In vivo subacute toxicity (28 days) and systemic chronic toxicity (40 days) studies were carried out in normal Swiss albino mice showed 1 is sinificantly nontoxic to the host.

专利号:US-11013831-B2
优先权日:2019-02-20
标 题:Methods of synthesis for a thioketal diol

专利号:US-2020261626-A1
优先权日:2019-02-20
标 题:Methods of synthesis for a thioketal diol