CAS: 6027-43-6; 3-(3,4-Dihydroxyphenyl)-1-(2,4,6-Trihydroxy-3-((2S,3R,4R,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Phenyl)Propan-1-One

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CAS号2280-44-6 D-glucopyranose | CAS号57765-66-9 eriodictyol dih... | CAS号1220779-38-3 3-(3,4-bis(benz...

📜3-(3,4-Bis(Benzyloxy)Phenyl)-1-(2,4,6-Tris(Benzyloxy)-3-((2S,3S,4R,5R,6R)-4,5-Bis(Benzyloxy)-6-((Benzyloxy)Methyl)-3-Hydroxytetrahydro-2H-Pyran-2-yl)Phenyl)Prop-2-Yn-1-One置于palladium 10% On Activated Carbon,氢气体系中,用 甲醇,乙酸乙酯 作为反应溶剂,化学反应 2.0H,以77%的收率获得产物阿司巴汀
参考文献:精简的天冬酰胺和nothofagin的总合成
标题:精简的天冬酰胺和nothofagin的总合成
摘要:C-糖基黄酮天然产物天冬酰胺和诺夫他汀的合成已由三苄基葡萄糖,三苄基间苯三酚和4-(苄氧基)苯乙炔或3,4-双(苄氧基)苯乙炔以八步完成.合成的关键步骤涉及高度立体选择性的路易斯酸促进1,2-二-O-酰基-3,4,6-三苄基葡萄糖与三苄基间苯三酚的偶联,从而在30-中产生相应的β-C-芳基糖苷65%的产率.
DOI:10.1021/ol100315G

专利信息

专利号:US-9181293-B2
优先权日:2009-11-24
标 题 :Method for the synthesis of aspalathin and analogues thereof
发明人：VAN DER WESTHUIZEN JAN HENDRIK; FERREIRA DANEEL; JOUBERT ELIZABETH; BONNET SUSSANA LUCIA
权利人:VAN DER WESTHUIZEN JAN HENDRIK; FERREIRA DANEEL; JOUBERT ELIZABETH; BONNET SUSSANA LUCIA; SOUTH AFRICAN MEDICAL RES COUNCIL
摘要:A method of synthesising Aspalathin and its analogues or derivatives is disclosed. The method comprises synthesising a compound of formula 1 or its analogues or derivatives: n n n n n n n n n n n n wherein n each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 is independently selected from the group consisting of —H, —OH, hydrocarbyl groups, saccharide moieties and —OR 15 ; n R 15 is selected from the group consisting of hydrogen, a hydrocarbyl group (e.g. methoxy or ethoxy), an acyl group and a benzyl group; and n R 11 , R 12 , R 13 and R 14 are independently selected from the group consisting of —H, hydrocarbyl groups, saccharide moieties, an acyl group and a benzyl group. The method comprises the step of coupling a sugar to a dihydrochalcone, chalcone or flavanone, or coupling the sugar to an intermediate for producing a dihydrochalcone, chalcone or flavanone followed by coupling of the sugar-intermediate adduct to a further intermediate for producing a dihydrochalcone, chalcone or flavanone, and transforming the product thereof into a compound of formula 1 or an analogue or derivative thereof.

专利号:US-12036300-B2
优先权日:2021-03-31
标题:Methods and compositions for improving skin
发明人：LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
权利人:OREAL
摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

专利号:US-2013018182-A1
优先权日:2009-11-24
标题:Method for the Synthesis of Aspalathin and Analogues Thereof

专利号:WO-2006042625-A2
优先权日:2004-10-15
标 题 :Compositions with inhibitors of the synthesis of prostaglandin and/or of leukotriene in conjunction with stimulators of the release of cutaneous neuromediators

专利号:WO-2011064726-A1
优先权日:2009-11-24
标 题:Method for the synthesis of aspalathin and analogues thereof

专利号:EP-1799311-A2
优先权日:2004-10-15
标 题:Compositions with inhibitors of the synthesis of prostaglandin and/or of leukotriene in conjunction with stimulators of the release of cutaneous neuromediators