CAS: 5469-26-1; 1-Bromo-3,3-Dimethyl-2-Butanone

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19967-55-6 2648-71-7 816-40-0

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CAS号75-97-8 频那酮 | CAS号558-37-2 3,3-二甲基-1-丁烯 | CAS号1271-66-5 双环戊二烯基二甲基钛 | CAS号24331-71-3 N,N-DIMETHYLPIV... | CAS号5682-67-7 3-[3-(dimethyla... | CAS号5581-94-2 3-(叔丁基)环戊酮 | CAS号3419-67-8 1-tert-butylcyc... | CAS号24417-23-0 3-tert-Butyl-1-... | CAS号104-94-9 对甲氧基苯胺 | CAS号70-11-1 2-溴苯乙酮 | CAS号104940-88-7 4,4-dimethyl-2-... | CAS号32278-16-3 3-叔丁基-3,4-二氢-2H... | CAS号144536-58-3 2-(3,3-dimethyl... | CAS号917-92-0 3,3-二甲基-1-丁炔 | CAS号1805-65-8 2-(叔丁基)-1H-吲哚 | CAS号406207-65-6 2-(叔丁基)咪唑并[1,2-a]吡啶 | CAS号19935-93-4 2-diethoxyphosp... | CAS号814-16-4 1-diethoxyphosp... | CAS号75-97-8 频那酮 | CAS号27610-88-4 2,2,7,7-四甲基-3,6-辛烷二酮

频哪酮置于溴体系中,用 乙醚 作为反应溶剂,化学反应 0.5H,以93%的收率获得产物1-溴频哪酮
参考文献:通过熵控制的亲电机制将氨,烷基胺和芳胺的分子间 N-H 氧化加成到平面 σ3-磷化合物中
标题:通过熵控制的亲电机制将氨,烷基胺和芳胺的分子间 N-H 氧化加成到平面 σ3-磷化合物中
摘要:发现氨,烷基胺和芳胺会发生快速的分子间 Nh 氧化加成到平面单核 σ(3)-磷化合物 (1).五配位正膦产物 (1.[h][nhr]) 结构坚固,可以通过多核 NMR 光谱和单晶 X 射线衍射进行全面表征.采用等温滴定量热法来量化正丙胺与 1 ((N)Prnh2 + 1-> 1.[h][nh(N)Pr] 的 Nh 氧化加成的焓,δhrxn(298) =-10.6 Kcal/摩尔).正丙胺 Nh 氧化加成的动力学由原位紫外吸收光谱和速率法测定显示出异常大的分子度 (ν = K[1][(N)Prnh2](3)).在 10-70 oc 的温度范围内进行的动力学实验表明,反应速率随着温度的升高而降低.从 Eyring 分析中提取的活化参数 (δh(⧧) =-0.8 +/-0.4 Kcal/mol,δs(⧧) =-72 +/-2 Cal/(Mol.k)) 表明强 Nh 键被 1 裂解为熵由于高度
DOI:10.1021/ja412469E

专利信息

专利号:US-6180718-B1
优先权日:1996-03-01
标题:Process for preparation of aromatic and heteroaromatic molecules
发明人：BOEHM TERRI L; HODGES JOHN C; SHOWALTER HOWARD D H
权利人:WARNER LAMBERT CO
摘要:A process for the attachment of aromatic or heteroaromatic rings to a polymeric support via a silyl ether linkage is described. Such process involves the synthesis of a chlorodialkyl aryl or heteroarylsilane which is then coupled to a polymeric support via a hydroxyl functionality to form a polymer-bound silyl ether. Further modification provides a polymer-bound small organic molecule that is cleaved from the polymeric support under mild conditions to give an aryl or heteroaryl silanol or a compound in which the aryl or heteroaryl carbon-silicon bond is replaced with a carbon-hydrogen, carbon-halogen, carbon-hydroxyl, carbon-sulfur, or carbon—carbon bond. Such methods are useful for the preparation of a library of diverse aromatic and heteroaromatic compounds by both manual and automated synthesis.

专利号:US-9018387-B2
优先权日:2010-06-11
标 题:Complexes of imidazole ligands
发明人：NORMAN JOHN ANTHONY THOMAS; PEREZ MELANIE K; LEI XINJIAN; SPENCE DANIEL P; IVANOV SERGEI VLADIMIROVICH; BAILEY III WADE HAMPTON
权利人:NORMAN JOHN ANTHONY THOMAS; PEREZ MELANIE K; LEI XINJIAN; SPENCE DANIEL P; IVANOV SERGEI VLADIMIROVICH; BAILEY III WADE HAMPTON; AIR PROD & CHEM
摘要:Metal imidazolate complexes are described where imidazoles ligands functionalized with bulky groups and their anionic counterpart, i.e., imidazolates are described. Compounds comprising one or more such polyalkylated imidazolate anions coordinated to a metal or more than one metal, selected from the group consisting of alkali metals, transition metals, lanthanide metals, actinide metals, main group metals, including the chalcogenides, are contemplated. Alternatively, multiple different imidazole anions, in addition to other different anions, can be coordinated to metals to make new complexes. The synthesis of novel compounds and their use to form thin metal containing films is also contemplated.

专利号:US-2010222601-A1
优先权日:2006-12-12
标题 :Synthesis of cyclopentadiene derivatives
发明人：TAHIRI OUARDIA; JONES ROBERT L; SCHIENDORFER MICHAEL; CHEVALIER REYNALD
权利人:BASELL POLYOLEFINE GMBH
摘要:A process for preparing cyclopentadiene derivatives having formula (I) n n n n n n n n n n Wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 equal to or different from each other, are hydrogen atoms or hydrocarbon groups comprising the steps of reacting a substituted or unsubstituted indanon with a base and then with a substituted or unsubstituted haloaceton and treating the obtained product with the Lawesson's reagent.

专利号:WO-9967219-A1
优先权日:1998-06-22
标 题:Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
发明人：AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
摘要:Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:WO-9966934-A1
优先权日:1998-06-22
标 题 :CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
发明人：AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.