CAS: 51186-58-4; Boc-D-Asp(Obzl)-Oh

相似化合物

7536-58-5 2177-63-1 3479-47-8

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号2177-63-1 L-天冬氨酸-β-苄酯 | CAS号1070-19-5 Carbonazidic ac... | CAS号77004-75-2 (R)-3-(B°C-氨基)-... | CAS号749208-35-3 B°C-d-beta-高丝氨酸

N-重氮基氨基甲酸叔-丁基酯,β-Benzyl-D-Aspartat 反应生成 叔丁氧羰基-D-天冬氨酸 4-苄酯
参考文献:杆菌肽的合成研究.九.环七肽式杆菌肽片段的合成
标题:杆菌肽的合成研究.九.环七肽式杆菌肽片段的合成
摘要:在杆菌肽的合成研究中,对应于杆菌肽 F 分支部分的肽片段,即 (S)-2-(2-Methylbutyryl)Thiazole-4-羧酸 1-琥珀酰亚胺酯 (Iii) 和 L-Leucyl-γ制备-叔丁基-D-谷氨酰-L-异亮氨酸(Iv).作为环七肽式杆菌肽a和f的大环部分,环-(Nα-苄氧羰基-L-赖氨酰-Nδ-环戊氧羰基-D-鸟基-L-异亮氨酰-D-苯丙氨酰-L-组氨酰-β-苄基-D-天冬氨酰-L-天冬酰胺(V)是通过氰甲基酯法合成的.
DOI:10.1246/bcsj.46.3835

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:CN-101220008-B
优先权日:2008-01-21
标题:Synthesis of compound ABT-263

专利号:CN-101220008-A
优先权日:2008-01-21
标题:Synthesis of compound ABT-263