CAS: 51-40-1; L-Noradrenaline Tartrate

📜2-氨基-3',4'-二羟基苯乙酮盐酸盐置于甲酸,Rucl[(S,S)-Teth-Tsdpen],三乙胺体系中,用 甲醇,水 作为反应溶剂,化学反应生成 重酒石酸去甲肾上腺素
参考文献:利用钌催化的无保护 α-酮胺的不对称转移氢化合成含手性 1,2-氨基醇的化合物
标题:利用钌催化的无保护 α-酮胺的不对称转移氢化合成含手性 1,2-氨基醇的化合物
摘要:在此,我们公开了一种简单的合成策略,以利用高效钌催化的未保护 α-酮胺的不对称转移氢化来获得一类重要的药物分子,这些分子包含手性 1,2-氨基官能团.最近,由于需求增加,Covid-19 大流行导致许多重要药物短缺危机,尤其是去甲肾上腺素和肾上腺素,用于治疗过敏反应和低血压.遗憾的是,由于现有的冗长合成方案需要额外的保护和脱保护步骤,因此现有技术无法满足全球要求.我们通过肾上腺素的高对映选择性一步法和去甲肾上腺素的两步法分别从未受保护的 α-酮胺 1B 和 1A 开始,确定了一种简单的合成方案.这种新开发的对映选择性钌催化的不对称转移氢化被扩展到许多含 1,2-氨基醇的药物分子的合成,如去氧肾上腺素,地诺巴胺,去甲布芽碱和左旋异丙肾上腺素,对映选择性为 >99% Ee,分离产率高.
DOI:10.1021/acs.Joc.4C00045

专利信息

专利号:US-2024366804-A1
优先权日:2021-07-30
标题 :Biocompatible imaging particles, their synthesis and use in imaging techniques
发明人：BONNARD THOMAS; JACQMARCQ CHARLÈNE; GAUBERTI MAXIME; MARTINEZ DE LIZARRONDO SARA; VIVIEN DENIS
权利人:INST NAT SANTE RECH MED; UNIV CAEN; CENTRE HOSPITALIER UNIV DE CAEN NORMANDIE
摘要:The present invention relates to novel biocompatible imaging particles comprising superparamagnetic iron oxide (SPIO) assembled into submicromiter-sized clusters within a biodegradable polycathecolamine or polyserotonine matrix, their synthesis and use in imaging techniques. These particles overcome the issues of toxicity and unreliable signal of the molecules from the prior art by providing similar contrast to that of the microparticles of iron oxide and rapidly disassemble into isolated SPIO particles once they reach the acidic lysosomal compartment of the MPS cells, thus enabling their digestion. The present invention is thus directed to a particle having a hydrodynamic diameter comprised between 100 nm and 2000 nm, said particle comprising nanoparticles of iron oxide embedded within a matrix of polycathecolamine or polyserotonine, each of said nanoparticles of iron oxide being coated by a polymer which is different from polycathecolamine or polyserotonine

专利号:US-6030613-A
优先权日:1995-01-17
标题:Receptor specific transepithelial transport of therapeutics
发明人：BLUMBERG RICHARD S; SIMISTER NEIL E; LENCER WAYNE I
权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS
摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

专利号:US-7547436-B2
优先权日:1995-01-17
标 题:Receptor specific transepithelial transport of therapeutics
发明人：BLUMBERG RICHARD S; LENCER WAYNE I; SIMISTER NEIL E
权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS
摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

专利号:CN-115073312-A
优先权日:2022-07-15
标题 :A new method for the synthesis of norepinephrine bitartrate

专利号:CN-112079733-A
优先权日:2020-09-25
标 题:A kind of method for asymmetric synthesis of norepinephrine bitartrate

专利号:CN-112079733-B
优先权日:2020-09-25
标题 :A kind of method for asymmetric synthesis of norepinephrine bitartrate