CAS: 501919-59-1; 2-Hydroxy-4-(2-(Tosyloxy)Acetamido)Benzoic Acid
该化合物是一种合成化合物,含有硫磺(S),碘(I)和氧(O),其特点是独特的分子结构,包括多种硫磺原子和碘,表明其在材料科学和医药化学等各个领域的潜在应用;碘的存在表明,它可能表现出与卤素化学有关的有趣特性,包括反应和潜在的抗微生物活动;此外,该化合物的原子具体安排在不同条件下可能具有独特的物理和化学特性,例如溶性,稳定性和再活性;与许多合成化合物一样,了解其在不同环境中的行为,包括与其他物质的互动,对于确定其实际应用至关重要;应当审查安全数据和处理防范措施,因为含有卤素的化合物可能带来风险;有必要进一步研究和定性,以充分阐明其特性和潜在用途.
物理性质
- 熔点>185°C (分解)
- 沸点654.7±55.0 °C(预测)
- 闪点349.8 °C
- 密度1.507
- pKa:2.98±0.10(预测)
- PSA:138.38
- LogP:2.8966
- 溶解性DMSO: >10mg/mL
- 外观形态白色至米色粉末
- 储存条件-20°C
- 产品应用该化合物是STAT3DNA约束性活动(IC50=86 ΜM)的选择性抑制剂,对STAT1和STAT5产生微弱抑制作用;它抑制STAT-3STAT 3 STAT3. DIMER 形成,而不受STAT-3激活状态的影响;抑制STAT3依赖的转录活动,并降低STAT-受STATD3管制的基因在环球D1,BCL-XL和SURVIVIN的表达方式;降低PS-727-STAT3(P3)水平和TGF-ET-蛋白质水平;抑制CD133+和CD133-HH-7细胞;加强黑-G2,HHH7和SK-HEP-1细胞的CETUXIMAB抗生化作用;在人类乳腺癌研究与治疗中,以5毫克/千克的剂量,无重大毒性或体重损失,显示老鼠乳腺癌模型(MDA-MB-231和HHH-7肝细胞癌模型)中的抗菌性反应作用;作为化学探测器抑制剂.
上下游产品
2-chloro-2-oxoethyl 4-methylbenzenesulfonate ethyl α-p-toluenesulfonyloxyacetate 2-(4-methylphenyl)sulfonyloxyacetic acid p-toluenesulfonyl chloride合成工艺路线路线简述
📜2-(P-甲苯磺酰氧基)乙酸置于sodium Hydroxide,氯化亚砜体系中,用 水 作为反应溶剂,化学反应 3.67H,反应生成 2-羟基-4-[[2-[[(4-甲基苯基)磺酰基]氧基]乙酰基]氨基]苯甲酸
参考文献:Wo2007/136858
标题:Wo2007/136858
海关参考信息
- 2906210000-苄醇
2912110000-甲醛
2912120000-乙醛
2912210000-苯甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2024336679-A1
优先权日:2021-08-06
标题 :Methods for the treatment of cancer
发明人：LINARES LÆTITIA; FIRMIN NELLY; MANTEAUX GABRIELLE
权利人:INST REGIONAL CANCER MONTPELLIER; INST NAT SANTE RECH MED; UNIV MONTPELLIER
摘要:The present disclosure relates to an Interleukin-6 (IL-6) signaling inhibitor selected from an IL-6 inhibitor, an IL-6 receptor inhibitor, an IL-6/IL-6 receptor complex inhibitor, a gp130 inhibitor and a STAT3 inhibitor or a pharmaceutical composition comprising such an IL-6 signaling inhibitor. for use in a method for treating and/or preventing cancer in a subject in need thereof. wherein the subject has been previously classified as being affected with a cancer exhibiting recruitment of MDM2 to chromatin. The inventors have observed that cancers exhibiting recruitment of MDM2 to chromatin have been shown to secrete IL-6 that in turn acts on myoblast cells to activate serine synthesis. Following these surprising and unexpected observations. the inventors set up methods of treatment that are able to induce cancer cells death in subjects that have been previously classified as being affected with a cancer exhibiting recruitment of MDM2 to chromatin.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Shen C, Wu N, Chen X, Peng J, Feng M, Wang J, Yu Y. Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway in angiotensin II-infused mice. J Cell Mol Med. 2024 Jul;28(13):e18493. doi: 10.1111/jcmm.18493.
2: Liu H, Yan R, Xiao Z, Huang X, Yao J, Liu J, An G, Ge Y. Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling. Breast Cancer Res. 2023 Apr 17;25(1):43. doi: 10.1186/s13058-023-01642-3.
3: Ji N, Wu L, Shi H, Li Q, Yu A, Yang Z. VSIG4 Attenuates NLRP3 and Ameliorates Neuroinflammation via JAK2-STAT3-A20 Pathway after Intracerebral Hemorrhage in Mice. Neurotox Res. 2022 Feb;40(1):78-88. doi: 10.1007/s12640-021-00456-5. Epub 2022 Jan 11.
合成参考文献
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
参考文献:10.1073/pnas.0609757104
摘要:Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 01;104(18):7391–6.
参考文献:10.1021/jm3017255
摘要:Page BD, Croucher DC, Li ZH, Haftchenary S, Jimenez-Zepeda VH, Atkinson J, Spagnuolo PA, Wong YL, Colaguori R, Lewis AM, Schimmer AD, Trudel S, Gunning PT. Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma. J Med Chem. 2013 Sep 26;56(18):7190–200. doi: 10.1021/jm3017255.
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