CAS: 4783-86-2; 4-Phenoxypyridine

该化合物是有机化合物,其特征是4点的环被一个苯氧类组取代,该化合物一般以纯度和形态为特征,无色可粉黄黄色液体或固体,因其芳香特性而闻名,在有机溶剂中可表现出中等溶解性,同时在水中不易溶解. 4-苯丙丙丙烯经常用于各种化学合成中,并可作为制药,农用化学品和其他有机化合物生产的中间体.其结构允许与生物系统进行潜在互动,使其在医药化学中引起兴趣.此外,它可能表现出典型的丙烯和苯氧基两种功能的特定再活性模式,包括核生殖器替代和电药用芳香替代.在处理时,应参考安全数据,因为如果吸入或摄入,可能会对健康造成危害.

结构式图片

相似化合物

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上下游产品

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合成工艺路线路线简述

  • 合成目标产物 4-Phenoxypyridine 主要起始原料 4-Aminopyridine
  • (文献来源)合成步骤主要原料 4-Aminopyridine
📜4-氨基吡啶 以 乙醇 作为反应溶剂,化学反应 31.0H,反应生成 4-苯氧基吡啶
参考文献:吡咯盐对氨基杂环的选择性功能化
标题:吡咯盐对氨基杂环的选择性功能化
摘要:提出了使用四氟硼酸吡啶鎓试剂(pyry-Bf 4)对氨基杂环进行官能化的方法.该试剂可与多种杂环胺有效地缩合,并为亲核芳香族取代反应准备c-N键.本文公开了用于形成co,Cn,Cs或cs 2 R键的60多个例子.与通过重氮化和多烷基化进行cn活化相反,该方法的特点是条件温和且对官能团的耐受力强.除小分子衍生化外,Pyry-Bf 4还允许以后期方式引入官能团,以提供高度官能化的结构.
DOI:10.1002/anie.201806271

海关参考信息

专利信息


专利号:US-3919155-A
优先权日:1970-12-18
标题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
发明人:SQUIRE EDWARD NOONAN
权利人:DU PONT
摘要:An improved process for producing an aromatic amine is provided in which an aromatic compound is reacted with ammonia in the presence of a conditioned nickel/nickel oxide cataloreactant at a temperature of from about 150*C. to about 500*C. and at a pressure of from about 10 to about 1000 atmospheres and in the presence of from 1 mole percent to 250 mole percent of water based on the molar amount of the aromatic compound.

专利号:US-4031106-A
优先权日:1973-12-19
标题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
发明人:DELPESCO THOMAS WAYNE
权利人:DU PONT
摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150 DEG C. to about 500 DEG C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant containing an oxide of lanthanum, samarium, holmium, europium, erbium, yttrium, praseodymium, neodymium, terbium, ytterbium, dysprosium or a mixture of any of them.

专利号:US-3929889-A
优先权日:1971-02-16
标 题 :Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
发明人:SQUIRE EDWARD NOONAN
权利人:DU PONT
摘要:An improved process for producing an aromatic amine is provided in which an aromatic compound is reacted with ammonia in the presence of a conditioned nickel/nickel oxide cataloreactant at a temperature of from about 150*C. to about 500*C. and at a pressure of from about 10 to about 1000 atmospheres.

专利号:US-4001260-A
优先权日:1973-12-19
标 题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
发明人:DEL PESCO THOMAS W
权利人:DU PONT
摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150° C. to about 500° C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant which has been treated with ammonia prior to introduction of the cataloreactant to the amination reactants.

专利号:CN-117304094-A
优先权日:2023-09-21
标 题 :Synthesis method of 3-trifluoromethyl pyridine or 3-difluoro methyl pyridine compound

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Synthesis Of Copper Nanoparticles Supported On A Microporous Covalent Triazine Polymer: An Efficient And Reusable Catalyst For O-Arylation Reaction
作者:Pillaiyar Puthiaraj,Wha-Seung Ahn
摘要:Cu Nps Immobilized On A Microporous Covalent Triazine Polymer Obtained By A Cost-Effective Synthesis Method Were Evaluated As A Catalyst For Ullmann Coupling Of O-Arylation.

合成参考文献


摘要:Yerien, D. E.; Barata-Vallejo, S.; Postigo, A., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 9.
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