CAS: 420-45-1; 2,2-Difluoropropane

该化合物是属于类异硫化合物的氟化碳氢化合物,其特征是,丙烷链第二碳中存在两个附属的氟原子,对丙烷链中的化学特性和反应作用有重大影响,该化合物一般是一种无色气体或室温液体,与非氟碳氢化合物相比,其沸点相对较低,其分子结构有助于其稳定性,使其反应能力低于其他碳氢化合物,尽管氟素的存在在某些条件下可以增强它的再活动性. 2,2,二氟丙烷经常用于各种用途,包括用作制冷剂,推进剂或工业工艺中的溶剂.此外,其氟化性质具有独特的特性,例如易燃性较低,热稳定性提高,使之适合于化学合成和材料科学中的具体用途.安全考虑对于处理该化合物非常重要,因为氟化物质可能对健康和环境产生影响.

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上下游产品

CAS号67-64-1 丙酮 | CAS号463-49-0 丙二烯 | CAS号594-20-7 2,2-二氯丙烷 | CAS号74-99-7 丙炔 | CAS号187737-37-7 propene | CAS号7664-39-3 氟化氢 | CAS号1871-72-3 1-bromo-2-fluor... | CAS号353-61-7 tert-butyl fluoride | CAS号65082-47-5 Methylsulfur tr... | CAS号2310-98-7 2-氯-2-溴丙烷 | CAS号1112-05-6 1,1,1-三氯-2,2-二氟丙烷 | CAS号420-99-5 1-氯-2,2-二氟丙烷 | CAS号3175-23-3 1,2,2-trichloro... | CAS号420-97-3 1,2-二氯-2-氟丙烷 | CAS号353-50-4 氟光气 | CAS号75-90-1 三氟乙醛 | CAS号680-00-2 1,1,2,2,3,3-hex... | CAS号76-19-7 八氟丙烷 | CAS号813-75-2 1,3-difluoro-2,... | CAS号811-94-9 1,2,2-Trifluoro...

合成工艺路线路线简述

    📜丙炔置于氢氟酸,镍体系中,化学反应生成 2,2-二氟丙烷
    参考文献:Grosse; Linn,Journal Of The American Chemical Society,1942,Vol. 64,P. 2291
    标题:Grosse; Linn,Journal Of The American Chemical Society,1942,Vol. 64,P. 2291

    专利信息


    专利号:US-11858953-B2
    优先权日:2018-04-04
    标 题:Compositions and methods for synthesis of phosphorylated molecules
    发明人:CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
    权利人:UNIV CALIFORNIA
    摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

    专利号:US-8987493-B2
    优先权日:2010-05-20
    标题 :Process for synthesis of silane dipeptide analogs
    发明人:SIEBURTH SCOTT MCNEILL; BO YINGJIAN
    权利人:SIEBURTH SCOTT MCNEILL; BO YINGJIAN; Temple University—Of the Commonwealth System of Higher Education
    摘要:The invention provides a method of preparing silane dipeptide analogs, comprising the steps of treating a solution of a substituted 1,2-oxasilolane with lithium metal to form a solution of the dilithium salt of a substituted 3-hydroxypropylsilanol, and reacting the solution of the dilithium salt of the substituted 3-hydroxypropylsilanol with a substituted enamine.

    专利号:US-9512250-B2
    优先权日:2012-02-23
    标 题 :Manganese catalyzed photopolymerization of fluorinated monomers
    发明人:ASANDEI ALEXANDRU D
    权利人:UNIV CONNECTICUT
    摘要:The disclosure discloses initiating systems for the radical polymerization of alkenes, and especially fluorine substituted alkenes. The polymerization is catalyzed by a metal carbonyl, preferably manganese carbonyl. The polymerization is initiated directly from alkyl halides at room temperature under visible white light. The polymers also allow the synthesis of block copolymers. The process comprises polymerizing at least one alkene monomer in the presence of a halide radical initiator, carbonyl catalyst and a solvent, under reaction conditions and for a time sufficient to polymerize the at least one alkene monomer to form a polymer. The present disclosure provides a method for living polymerization of alkene monomers which provides a high level of macromolecular control over the polymerization process and which leads to uniform and controllable polymeric products. This disclosure also provides a method for activating any halide (Cl, Br, I) chain ends of such polymers for the synthesis of block copolymerizations.

    专利号:US-2012083627-A1
    优先权日:2010-10-01
    标 题:Method of Synthesis of Arylsulfur Trifluorides and Use as in situ Deoxofluorination Reagent
    发明人:DOLBIER JR WILLIAM R; XU WEI
    权利人:DOLBIER JR WILLIAM R; XU WEI; FLUOROTECH LLC; OAKWOOD PRODUCTS INC
    摘要:The invention is a method of synthesizing Arylsulfur Trifluorides, such as Fluolead, by reacting BR 2 and KF (or suitable alkali metal fluoride) in acetonitrile (or other suitable solvent). The invention also comprises using the Fluolead (or its substitutes), thus prepared, in situ as deoxofluorination reagents with a suitable aldehyde, ketone, or alcohol such as one selected from the group consisting of benzaldehyde Benzaldehyde, p-Bromobenzaldehyde, p-Tolualdehyde, Acetophenone, 2-Butanone, or Isobutyraldehyde, wherein the mixture is heated to reflux until completion. The respective products are then isolated after extraction by hexane and destruction of the sulfinyl fluoride co-product.

    专利号:US-9175026-B2
    优先权日:2011-03-23
    标题:Synthesis of thioether containing trialkoxysilanes
    发明人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K
    权利人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K; UNIV CALIFORNIA
    摘要:The invention relates to a radical-initiated thiol-ene or thiol-yne “clickâ€? reaction that provides a simple and efficient route to diverse trialkoxysilanes. Trialkoxysilanes made in this way are obtained in quantitative to near-quantitative yields with high purity without any or minimal purification. A wide range of functional groups is tolerated in this approach, and even complex alkenes click with the silane precursors. The modular nature of these radical-based thiol-ene or thiol-yne “clickâ€? reactions allows a wide variety of pendant groups to be coupled to silane compounds that can then be coupled to a wide variety surfaces in order to modify their material properties. Consequently, such radical initiated thiol-ene and thiol-yne reactions provide facile and efficient methods for preparing an enormous number of surface-active functional trialkoxysilanes.

    专利号:US-7612106-B2
    优先权日:2004-12-23
    标题 :Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof
    发明人:BOATMAN P DOUGLAS; SCHRADER THOMAS O; SEMPLE GRAEME; SKINNER PHILIP J; JUNG JAE-KYU
    权利人:ARENA PHARM INC
    摘要:The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. n nAlso provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

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    合成参考文献


    参考文献:10.1021/jo016241m
    摘要:Bach RD, Dmitrenko O. The effect of substitutents on the strain energies of small ring compounds. J Org Chem. 2002 Apr 19;67(8):2588–99. doi: 10.1021/jo016241m.
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