CAS: 403-42-9; 1-(4-Fluorophenyl)Ethanone

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CAS号350-40-3 4-氟-α-甲基苯乙烯 | CAS号403-41-8 1-(4-氟苯基)乙醇 | CAS号766-98-3 4-氟苯乙炔 | CAS号438569-05-2 p-(TRIETHOXYSIL... | CAS号111-34-2 乙烯基正丁醚 | CAS号460-00-4 对氟溴苯 | CAS号462-06-6 氟苯 | CAS号108-24-7 乙酸酐 | CAS号17983-61-8 (4-acetylphenyl... | CAS号106991-88-2 1-[4-[4-[4-(4-a... | CAS号104940-89-8 1-(4-fluorophen... | CAS号403-29-2 2-溴-4'-氟苯乙酮 | CAS号7542-64-5 2,2-二溴-4'-氟苯乙酮 | CAS号456-03-1 4'-氟苯丙酮 | CAS号35114-93-3 1-[4-(4-氟苯氧基)苯基]乙酮 | CAS号347-12-6 2-(4-氟苯基)咪唑并[1,... | CAS号31776-83-7 2-氯-6-(4-氟苯基)烟酸腈 | CAS号33282-24-5 5-(4-氟苯基)-异恶唑-3-羧酸 | CAS号306936-57-2 3-(4-氟苯基)吡唑-4-甲醛

2-氯-4-氟苯乙酮置于异丙醇体系中,化学反应 15.0H,以87%的收率获得产物4-氟苯乙酮
参考文献:用于用可见光解锁有机卤化物的陶瓷碳氮化硼
标题:用于用可见光解锁有机卤化物的陶瓷碳氮化硼
摘要:光化学通过电子转移过程从底物中诱导自由基中间体,为有机转化提供了可持续的途径.然而,进展受到多相光催化剂的限制,这些光催化剂需要高效,稳定,廉价才能长期运行,并且易于回收和产品分离.在这里,我们报道碳氮化硼(bcn)陶瓷就是这样一个系统,可以在可见光照射下减少有机卤化物,包括(杂)芳基和烷基卤化物.卤化物的交叉偶联可在环境反应条件下进行,以提供新的 C-H,C-C 和 C-S 键.在没有任何金属基催化剂或配体的情况下,通过介晶 C-X(碳-卤素)键断裂将氢,(杂)芳基和磺酰基引入芳烃和杂芳烃的设计位置. Bcn不仅可用于半反应,例如与牺牲剂的还原反应,还可用于通过氧化和还原界面电子转移的氧化还原反应. Bcn 光催化剂表现出对不同取代基的耐受性,并且在五次回收后活性保持不变.这种表面上不含金属的系统为使用光能和可持续材料的各种有机催化剂开辟了新的机遇,这些催化剂不含金属,廉价且稳定.
DOI:10.1039/d1Sc01028J

专利信息

专利号:US-10308588-B2
优先权日:2014-12-15
标 题 :Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
发明人：CÓRDOVA ARMANDO; PALO-NIETO CARLOS; AFEWERKI SAMSON
权利人:ORGANOFUEL SWEDEN AB
摘要:A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人：CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:US-4871873-A
优先权日:1988-03-18
标 题:Process for synthesis of arylglyoxal arylimines
发明人：DESMOND RICHARD; MILLS SANDER G; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process for producing arylglyoxal arylimine intermediates, by the DMSO/HBr oxidation of arylmethylketones. The imine compounds are intermediates in the synthesis of carbapenem antibiotics, i.e. imipenem.

专利号:US-6096883-A
优先权日:1996-05-31
标 题 :3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones
发明人：WU GEORGE G; CHEN XING; WONG YEE-SHING; SCHUMACHER DORIS P; STEINMAN MARTIN
权利人:SCHERING CORP
摘要:The invention relates to intermediates of the formulae ##STR1## said intermediates being useful in a process for producing a compound of the formula ##STR2## wherein Bn is benzyl and R 1 , 2 and R 3 are as defined in the specification,

专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

专利号:US-2024239805-A1
优先权日:2022-12-16
标 题:Aza-yang cyclization-buchner aromatic ring expansion: collective synthesis of cycloheptatriene-containing azetidine lactones
发明人：SINGH MANVENDRA PAL; BOSKOVIC ZARKO; GASKINS BRYCE
权利人:UNIV KANSAS
摘要:The present disclosure is directed to a compound of Formula I, Formula II, Formula III, Formula IV, or Formula Vor a pharmaceutically acceptable salt and/or solvate thereof.