CAS: 3844-94-8; 1-Trimethylsilyl-1-Hexyne

相似化合物

62108-37-6 15719-56-9 113964-33-3

上下游产品

6-溴己-1-炔基(三甲基)硅烷 (5-Bromo-Pent-1-Ynyl)-Trimehyl-Silane 91656-99-4
5-Hexen-1-Ynyltrimethylsilane 1578-50-3

📜1-己炔 以94%的收率获得
参考文献:Miller R. B.; Mcgarvey G.,J. Org. Chem.,1978,43,No 23,4424-4431
标题:Miller R. B.; Mcgarvey G.,J. Org. Chem.,1978,43,No 23,4424-4431

专利信息

专利号:US-7906501-B2
优先权日:2004-04-28
标题:Pyrrole derivatives with angiotensin II antagonist activity
发明人：MAKOVEC FRANCESCO; ARTUSI ROBERTO; GIORDANI ANTONIO; ZANZOLA SIMONA; ROVATI LUCIO CLAUDIO
权利人:ROTTAPHARM SPA
摘要:Compounds which may be represented by the general formula (I) shown below and in which: R 1 is a group independently selected from among: CHO, —COOH, —CH 2 OH R 2 is hydrogen or a linear or branched C 1 -C 6 alkyl group R 3 is hydrogen or a halogen group selected from among Cl and Br R 4 is a linear or branched C 3 -C 5 alkyl group and the pharmaceutically acceptable salts thereof such as the sodium or potassium salt. The compounds exhibit potent and selective All antagonist activity and are useful for the treatment of any disorders in which elevated synthesis of All or overexpression of the AT 1 receptor may play a primary pathological role, as in the case of arterial hypertension, congestive cardiac insufficiency, platelet aggregation and disorders associated therewith such as for example myocardial and cerebral infarction, renal ischaemia, venous and arterial thrombosis, peripheral vasculopathy, pulmonary hypertension, diabetes mellitus, diabetic neuropathy, glaucoma and diabetic retinopathy.