专利号:US-5214218-A 优先权日:1992-05-04 标题 :One step synthesis of methyl t-butyl ether from t-butanol using haloacid-modified clay catalysts 发明人:KNIFTON JOHN F 权利人:TEXACO CHEMICAL 摘要:A method is disclosed wherein t-butanol is reacted with methanol in a reaction zone in one step to provide methyl tert-butyl ether and the improvement of accomplishing the reaction which comprises: n a. Using a catalyst comprising a montmorillonite clay treated with a haloacid; n b. continuously contacting said t-butanol and methanol in a molar amount of about 0.1 to 10 moles of methanol per mole of t-butanol with said catalyst at a temperature of about 20° C. to about 250° C. and a pressure of about atmospheric to about 1000 psig to obtain the methyl tert-butyl ether product.
专利号:US-8138272-B2 优先权日:2006-05-22 标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds 发明人:KONRADI ANDREI W; SMITH JENIFER L 权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC 摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.
专利号:US-2022056053-A1 优先权日:2019-05-06 标 题:Synthesis of crac channel inhibitors 发明人:STAUDERMAN KENNETH A; DUNN MICHAEL; WHITTEN JEFFREY P; ROGERS EVAN 权利人:CALCIMEDICA INC 摘要:A convergent synthetic method for the production of CRAC channel inhibitors is described herein. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.
专利号:US-12344592-B2 优先权日:2020-01-17 标题 :Methods, processes and intermediates for preparing chroman compounds 发明人:KAMBOJ RAJENDER KUMAR; PADIYA KAMLESH JYOTINDRA; PRABAKARAN KAMALAKANNAN; NAIK KUMAR RAM; RAJESH BHAVANI SHANKAR; RAJENDRA GANPATI POWAR; SACHIN SUBHASH INGAWALE; AMIT DATTATRAY KARCHE; SANTOSHKUMAR SHANKAR DANGE; SITARAM RAMBHAU BARVE 权利人:LUPIN LTD 摘要:This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.
专利号:US-10125226-B2 优先权日:2013-06-05 标 题 :Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils 发明人:FLORES SANDOVAL CESAR ANDRES; FLORES OROPEZA EUGENIO ALEJANDRO; LOPEZ ORTEGA ALFONSO; HERNANDEZ CORTEZ JOSE GONZALO; ESTRADA BUENDIA ARISTEO; CASTRO SOTELO LAURA VERONICA; REYES MARTINEZ REYNA; ALVAREZ RAMIREZ FERNANDO; ESTRADA MARTINEZ ARQUIMEDES; VAZQUEZ MORENO FLAVIO SALVADOR 权利人:MEXICANO INST PETROL 摘要:A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POEw-POPy-POEw) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.
专利号:CN-111885917-A 优先权日:2018-01-23 标 题:Synthesis of 5-chloro-2-[(3,4,4-trifluoro-3-buten-1-yl)thio]-thiazole