CAS: 21906-39-8; 1-[3-(Trifluoromethyl)Phenyl]-2-Propanone

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CAS号108-22-5 醋酸异丙烯酯 | CAS号98-16-8 间三氟甲苯胺 | CAS号401-78-5 间溴三氟甲苯 | CAS号78-95-5 氯丙酮 | CAS号368-79-6 3-Isopropenylbe... | CAS号108-24-7 乙酸酐 | CAS号705-29-3 3-三氟甲基氯苄 | CAS号713-71-3 2-[3-(trifluoro... | CAS号1139705-23-9 3-(trifluoromet... | CAS号67-64-1 丙酮 | CAS号458-24-2 左芬氟拉明 | CAS号19036-73-8 (S)-1-(3-三氟甲基苯基... | CAS号31173-14-5 2-[[1-methyl-2-... | CAS号38060-02-5 1-[m-(Trifluoro... | CAS号52271-40-6 N-ethyl-N-[1-[3...

📜(E)-1-Phenyl-N-{1-[3-(Trifluoromethyl)Phenyl]Prop-1-En-2-Yl}Methanimine置于水,草酸体系中,化学反应生成3-三氟甲基苯丙酮
参考文献:α-Aminophosphonates: I. Synthesis Of 2-Azadienes And Their Hydrolysis To Carbonyl Compounds
标题:α-Aminophosphonates: I. Synthesis Of 2-Azadienes And Their Hydrolysis To Carbonyl Compounds
摘要:
Doi:10.1055/s-1977-24449

专利信息

专利号:US-5811586-A
优先权日:1996-05-29
标 题 :Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-one intermediate in the synthesis of the fenfluramine
发明人：CANNATA VINCENZO; GALBIATI BARBARA; SPREAFICO ANGELO
权利人:ALFA CHEM ITAL
摘要:A process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the anorexic drug fenfluramine consists of reacting the diazonium salt of 3-trifluoromethylaniline with isopropenyl acetate in a polar solvent in the presence of a catalytic amount of a cuprous salt and, optionally, of a base and purifying the crude product through the bisulfite complex or distillation under vacuum.

专利号:EP-1075534-B8
优先权日:1998-03-11
标 题 :Improvements in the enzymatic synthesis of chiral amines
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-5808156-A
优先权日:1997-04-28
标题 :Process for the production of the isomers (R) and (S)-α-methyl-3(trifluoromethyl)benzeneethanamine
发明人：CANNATA VINCENZO; GALBIATI BARBARA; FERRARIO TIZIANO
权利人:ALFA CHEM ITAL
摘要:Process for the production of the isomers (R) and (S)-α-methyl-3-(trifluoromethyl)benzeneethanamine, the second being useful as intermediate in the synthesis of the anorexic drug dexfenfluramine (INN), which comprises carrying out a stereospecific reductive amination of 1-(3-trifluoromethyl)phenyl-2-propanone with (R) or (S)-α-methylbenzylamine under a hydrogen atmosphere in the presence of a catalyst and debenzylating the resulting diastereoisomer (R),(R) or (S),(S)-N-(1-phenylethyl)-α-methyl-3-(trifluoromethyl)benzeneethanamine by treatment with hydrogen and a catalyst.

专利号:US-2018208543-A1
优先权日:2017-01-26
标 题 :New method for synthesis of fenfluramine, and new compositions comprising it
发明人：PALOMBI GIOVANNI; ZAGAMI MICHAEL
权利人:FRAU PHARMA S R L
摘要:A new process for preparing the fenfluramine molecule and new compositions containing fenfluramine obtainable with the claimed process.

专利号:EP-3170807-A1
优先权日:2015-11-23
标题:New method for synthesis of fenfluramine, of isomers therof and/or of analogs thereof, and new compositions comprising it

专利号:EP-0810195-A1
优先权日:1996-05-29
标题:Process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the fenfluramine