CAS: 19943-27-2; (5As,10As)-Octahydro-5H,10H-Dipyrrolo[1,2-A:1',2'-D]Pyrazine-5,10-Dione
该化合物是一种由两个分泌氨酸组成的环状二极酸,由两个分泌氨酸组成,在头到尾安排中相连.该化合物的特点是独特的环状结构,它影响其同质特性和生物活动.分泌残留物的存在有助于其僵硬性,并能够采用特定的三维形状,这对与生物目标的互动至关重要.Cyclo(L-prolyl-L-prolyl)因其在各种生物过程中的潜在作用而著称,包括作为信号分子或影响蛋白折叠.其稳定性和抗酶降解性使其对制药和生物化学研究感兴趣.此外,该化合物的特性,例如溶解性和再活性,可以因周围环境,包括pH和溶剂条件而不同.
- 英文名称(5As,10As)-Octahydro-5H,10H-Dipyrrolo[1,2-A:1',2'-D]Pyrazine-5,10-Dione
- 中文名称(5AS,10aS)-八氢-5H,10H-二吡咯烷[1,2-a:1',2'-d]吡嗪-5,10-二酮
- IUPAC名称(5AS,10aS)-octahydro-5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-5,10-dione
- 其它别名维达列汀杂质5; (3S,9S)-1,7-Diazatricyclo[7.3.0.03,7]Dodecane-2,8-Dione
- CAS编号19943-27-2
- MFCD编号:MFCD00191007
- FDA UNII编号:XGU973420W
- 分子式:C10H14N2O2分子量:194.23
- 产品CID: 1014164
- 产品分类有机原料→分子砌块→脂肪杂环类化合物→吡咯烷类化合物
相似化合物
3705-27-9 19179-12-5 96193-26-9MSDS等安全信息
上下游产品
prolyl>prolineN-prolylproline prolyl>prolineN-prolylproline butan-1-ol methyl (2S)-pyrrolidine carboxylatea;1',2'-d]pyrazine-5,10-dione5a-benzyl-°Ctahydro-dipyrrolo[1,2-a;1',2'-d]pyrazine-5,10-dione a;1',2'-d]pyrazine-5a-carboxylic acid benzyl ester5,10-dioxo-hexahydro-dipyrrolo[1,2-a;1',2'-d]pyrazine-5a-carboxylic acid benzyl ester (-)-(2R,3R)-trans-2,3-bis(hydroxydiphenylmethyl)-1,4-dioxaspiro[4.5]decane合成工艺路线路线简述
📜L-脯氨酸甲酯盐酸盐置于potassium Carbonate体系中,化学反应生成维格列汀杂质
参考文献:手性叔胺/l-脯氨酸共催化的对映选择性 Morita-Baylis-Hillman (Mbh) 反应
标题:手性叔胺/l-脯氨酸共催化的对映选择性 Morita-Baylis-Hillman (Mbh) 反应
摘要:从容易获得的手性来源开始,已经合成了四种类型的手性胺.已发现这些手性胺与 L-脯氨酸结合是甲基乙烯基酮 (Mvk) 和芳香醛之间不对称 Morita-Baylis-Hillman (Mbh) 反应的有效助催化剂.相应的加合物以合理的化学产率和非常好的对映选择性(高达 83% Ee)形成.此外,与手性胺 4 和 L-脯氨酸的两种对映异构体的平行共催化反应表明,脯氨酸立体化学决定了新形成的手性中心的构型.此外,胺4A中游离羟基的存在提高了反应的对映选择性.基于这些发现,已经提出了这种助催化 Mbh 反应的合理机制.
Doi:10.1002/ejoc.200700794
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺
2924191000-二甲基甲酰胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9045381-B2
优先权日:2010-10-19
标 题:Ruthenium complexes and their uses in processes for formation and/or hydrogenation of esters, amides and derivatives thereof
发明人：MILSTEIN DAVID; BALARAMAN EKAMBARAM; GUNANATHAN CHIDAMBARAM; GNANAPRAKASAM BOOPATHY; ZHANG JING
权利人:MILSTEIN DAVID; BALARAMAN EKAMBARAM; GUNANATHAN CHIDAMBARAM; GNANAPRAKASAM BOOPATHY; ZHANG JING; YEDA RES & DEV
摘要:The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Collier, S. J., Science of Synthesis, (2007) 20, 679.
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