CAS: 19891-74-8; Lycoxanthin

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      专利号:US-7247752-B2
      优先权日:2004-10-01
      标 题 :Methods for the synthesis of astaxanthin
      发明人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID
      权利人:CARDAX PHARMACEUTICALS INC
      摘要:A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.

      专利号:US-7435861-B2
      优先权日:2005-04-29
      标 题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
      发明人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID
      权利人:CARDAX PHARMACEUTICALS INC
      摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

      专利号:US-2008221377-A1
      优先权日:2006-06-16
      标题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
      发明人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
      权利人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
      摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

      专利号:US-2006111580-A1
      优先权日:2004-10-01
      标 题 :Methods for the synthesis of chiral dihydroxy ketone intermediates useful for the chiral synthesis of carotenoids

      专利号:US-2006167319-A1
      优先权日:2004-10-01
      标题:Methods for the synthesis of unsaturated ketone intermediates useful for the synthesis of carotenoids

      专利号:US-2006178538-A1
      优先权日:2004-10-01
      标题:Methods for the synthesis of chiral dihydroxy intermediates useful for the chiral synthesis of carotenoids

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      合成参考文献


      参考文献:10.1016/0031-9422(73)85095-2
      摘要:Ben-Aziz A, Britton G, Goodwin TW. Carotene epoxides of Lycopersicon esculentum. Phytochemistry. 1973 Nov;12(11):2759–64. doi: 10.1016/0031-9422(73)85095-2.
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