CAS: 1955-68-6; L-Aspartic Acid β-Hydroxamate

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5794-13-8 5794-24-1 69833-18-7

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L-天冬酰胺 L-Asparagine 70-47-3

合成工艺路线路线简述

    📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于盐酸,甲醇,羟胺,三乙胺体系中,化学反应生成L-天冬氨酰-β-异羟肟酸
    参考文献:De Groot; Lichtenstein,1959,Vol. 8,P. 116
    标题:De Groot; Lichtenstein,1959,Vol. 8,P. 116

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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
    [参考文献]: D A Gibson, Et Al. Estrogen-Dependent Regulation Of Human Uterine Natural Killer Cells Promotes Vascular Remodelling Via Secretion Of Ccl2. Hum Reprod. 2015 Jun;30(6):1290-301.
    [参考文献]: Der-Zen Liu, Et Al. Monohydroxamates Of Aspartic Acid And Glutamic Acid Exhibit Antioxidant And Angiotensin Converting Enzyme Inhibitory Activities. J Agric Food Chem. 2004 Apr 21;52(8):2386-90.
    [参考文献]: Febe Van Maldegem, Et Al. Ctnnbl1 Facilitates The Association Of Cwc15 With Cdc5L And Is Required To Maintain The Abundance Of The Prp19 Spliceosomal Complex. Nucleic Acids Res. 2015 Aug 18;43(14):7058-69.
    [参考文献]: Gerard Quash, Et Al. 4-Methylthio 2-Oxobutanoate Transaminase: A Specific Target For Antiproliferative Agents. Bull Cancer. 2004 Apr;91(4):E61-79.

    合成参考文献


    参考文献:10.1186/1472-6807-12-14
    摘要:Chaikuad A, Pilka ES, De Riso A, von Delft F, Kavanagh KL, Vénien-Bryan C, Oppermann U, Yue WW. Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family. BMC Molecular and Cell Biology. 2012 Jun 21;12(1):14. doi: 10.1186/1472-6807-12-14.
    参考文献:10.1021/jm900775q
    摘要:Hoffman HE, Jirásková J, Cígler P, Sanda M, Schraml J, Konvalinka J. Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor. J Med Chem. 2009 Oct 08;52(19):6032–41. doi: 10.1021/jm900775q.
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