对氟苯甲醚置于盐酸,乌洛托品,硫酸,溶剂黄146体系中,化学反应 5.0H,反应生成5-氟-2-甲氧基苯甲醛 参考文献:Vallaerda,Jerk; Appelberg,Ulf; Csoeregh,Ingeborg,Journal Of The Chemical Society. Perkin Transactions I,1994,# 4,P. 461-470 标题:Vallaerda,Jerk; Appelberg,Ulf; Csoeregh,Ingeborg,Journal Of The Chemical Society. Perkin Transactions I,1994,# 4,P. 461-470
专利号:US-11795168-B2 优先权日:2020-09-23 标 题:Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) 发明人:LUKE GEORGE; BABU SURESH 权利人:FORMA THERAPEUTICS INC 摘要:The present disclosure is directed to solid and salt forms of inhibitors of the CBP/p300 family of bromodomains made up of salts and crystalline forms of Formula (I). The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains (e.g., certain forms of cancer), and methods of synthesis of these compounds.
专利号:US-12378242-B2 优先权日:2018-06-29 标题 :Inhibiting CREB binding protein (CBP) 发明人:SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST Angela; DOWNING JENNIFER R; ERICSSON ANNA 权利人:FORMA THERAPEUTICS INC 摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.
专利号:US-11787803-B2 优先权日:2017-09-15 标 题 :Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors 发明人:SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST ANGELA V; DOWNING JENNIFER R; ERICSSON ANNA 权利人:FORMA THERAPEUTICS INC 摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.
专利号:CN-101535239-A 优先权日:2006-11-09 标题 :Synthesis of selected stereoisomers of certain substituted alcohols
专利号:US-4908380-A 优先权日:1986-11-04 标题:Pharmaceutical compositions 发明人:BREWSTER ANDREW G; BROWN GEORGE R; SMITHERS MICHAEL J 权利人:ICI PLC 摘要:The invention concerns novel pharmaceutical compositions containing a 4(Z)-6-(2,4-diphenyl-1,3-dioxan-5-yl)-alkenoic acid which antagonizes one or more of the actions of thromboxane A2, together with a compound which inhibits the synthesis of thromboxane A2. The compositios are useful as medicines in treating a variety of diseases or medical conditions in which thromboxane A2 and/or other prostanoid contractile substances are involved.
专利号:US-7781470-B2 优先权日:1999-09-13 标题:Aminodicarboxylic acid derivatives having pharmaceutical properties 发明人:ALONSO-ALIJA CRISTINA; HEIL MARKUS; FLUBACHER DIETMAR; NAAB PAUL; PERNERSTORFER JOSEF; STASCH JOHANNES-PETER; WUNDER FRANK; DEMBOWSKY KLAUS; PERZBORN ELIZABETH; STAHL ELKE 权利人:BAYER SCHERING PHARMA AG 摘要:The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, n nwherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.