CAS: 16711-71-0; 3,5-D-Diiodo-Tyr-Oh

该化合物是氨基酸乙酰胺的卤化衍生物,其特点是在芳香环的3和5个位置替换碘原子,这一修改加强了其在生化和制药研究中的效用,特别是在涉及甲状腺激素合成和新陈代谢的研究中的效用.该化合物是生产甲状腺素(T4)和三碘二苯乙烯(T3)的关键中间体.其高纯度和稳定性使它适合用于放射性标签,酶抑制检测和作为参考标准.3,5-Diodo-D-苯罗辛的结构性特性确保了分析和合成应用的可靠性能.

结构式图片

相似化合物

66-02-4 300-39-0 103213-31-6

上下游产品

CAS号556-02-5 D-酪氨酸 | CAS号51-49-0 D-甲状腺素

合成工艺路线路线简述

    D-酪氨酸置于sodium Hydroxide,碘体系中,化学反应生成D-3,5-二碘酪氨酸
    参考文献:Abderhalden,Pflugers Archiv Fur Die Gesamte Physiologie Des Menschen Und Der Tiere,1923,Vol. 201,P. 432,441
    标题:Abderhalden,Pflugers Archiv Fur Die Gesamte Physiologie Des Menschen Und Der Tiere,1923,Vol. 201,P. 432,441

    海关参考信息

    专利信息


    专利号:US-2022243244-A1
    优先权日:2019-10-10
    标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
    发明人:ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
    权利人:SCRIPPS RESEARCH INST
    摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

    专利号:US-2023037284-A9
    优先权日:2018-11-30
    标题:Combination therapy of peptidomimetic macrocycles
    发明人:GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
    权利人:AILERON THERAPEUTICS INC
    摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

    专利号:US-2025084410-A1
    优先权日:2015-01-12
    标 题:Incorporation of unnatural nucleotides and methods thereof
    发明人:PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
    权利人:SYNTHORX INC
    摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

    专利号:US-2018371021-A1
    优先权日:2017-05-11
    标 题 :Peptidomimetic macrocycles and uses thereof
    发明人:AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
    权利人:AILERON THERAPEUTICS INC
    摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

    专利号:WO-2021072167-A1
    优先权日:2019-10-10
    标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides

    专利号:US-11091522-B2
    优先权日:2018-07-23
    标题 :Peptidomimetic macrocycles and uses thereof
    发明人:AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN; ANNIS DAVID ALLEN
    权利人:AILERON THERAPEUTICS INC
    摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

    合成参考文献


    参考文献:10.1007/978-3-642-92166-7_48
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