CAS: 14901-16-7; 1-Phenyl-3-(Thiazol-2-yl)Thiourea
该化合物是一种含有一个苯基组和氮原子硫化物替代物的硫尿素衍生物,该化合物具有有机合成和协调化学的作用,因为它具有多种功能,与过渡金属形成稳定的复合体,其结构特征,包括富电子的硫酸盐环,增强了其结合性和选择性.该产品还被用作制药和农用化学研究的前体或中间体,用于生物活性分子的开发,其稳定性和再活性使其适合需要精确分子修改的应用.建议妥善处理和储存以保持其完整性.
- 英文名称1-Phenyl-3-(Thiazol-2-yl)Thiourea
- 中文名称苯基-3-(2-噻唑基)-2-硫脲
- IUPAC名称1-phenyl-3-(thiazol-2-yl)thiourea
- 其它别名1-Phenyl-3-(2-Thiazolyl)-2-Thiourea; 1-Phenyl-3-(Thiazol-2-yl)Thiourea; Thiourea, N-Phenyl-N'-2-Thiazolyl-; Phenylthiazolylthiourea; 1-Phenyl-3-(2-Thiazolyl)Thiourea; 1-Phenyl-3-(1,3-Thiazol-2-yl)Thiourea; Urea, 1-Phenyl-3-(2-Thiazolyl)-2-Thio-; Mls00
- CAS编号14901-16-7
- MFCD编号:MFCD00005321
- EINECS号:238-970-4
- FDA UNII编号:YLB873BH59
- 分子式:C10H9N3S2分子量:235.34
- 产品CID: 716914
- 产品分类化学试剂 → 有机试剂 → 硫脲
物理性质
- 熔点183-185 °C (分解)(文献)
- 沸点>183-185 °C (分解)(文献)
- 闪点178.1 °C
- 密度1.3479 (粗估)
- PSA:97.28
- LogP:3.098
- 折射率1.5500 (估算)
- 蒸汽压1.08E-05 mmHg at 25 °C
- 外观形态light brown fine crystalline powder
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是一种强效多巴胺乙型氢氧LAS抑制剂;它抑制氨基苯丙胺N-DEMOTHYASE,乙酰乙酰苯乙烯和P-NITROANISOLE O-DEMETAYASE的活动.
MSDS等安全信息
- GHS象形图
- GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion - 危险类别急性毒性 类别4(经口)
严重眼损伤 类别1
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2 - 警示词Danger(危险)
- 危险描述H302 |吞咽有害.
H318 |造成严重眼损伤.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激. - 防范说明P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501
- 危险品标志Xn
- 安全声明S26,S39
- 危险类别码R22,R41,R37/38
- WGK Germany3
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
2-thiazolylamine phenyl isothi°Cyanate 2-methyl-1-phenyl-3-thiazol-2-yl-isothiourea (N-phenyl-N'-(2-thiazolyl) thiourea)2 Cd(II) (N-phenyl-N'-(2-thiazolyl) thiourea)2 zinc(II) (N-phenyl-N'-(2-thiazolyl) thiourea)2 Hg(II)合成工艺路线路线简述
📜反应生成四氰基乙烯,苯基-3-(2-噻唑基)-2-硫脲
参考文献:Mohamed; Hassan; Ibrahim,Pharmazie,1992,Vol. 47,# 8,P. 592-595
标题:Mohamed; Hassan; Ibrahim,Pharmazie,1992,Vol. 47,# 8,P. 592-595
专利信息
专利号:US-11958866-B1
优先权日:2023-04-07
标题:Synthesis of thiazole derivatives
发明人：NOOR AWAL; KHAN EZZAT; KHAN UMAR ALI
权利人:UNIV KING FAISAL
摘要:A synthetic protocol to use a thiourea or urea compound and auric chloride as starting materials to obtain thiazole and benzothiazole derivatives. The synthesis can be conducted at room temperature and the final compound can result from cyclization of the thiourea or urea compound in the presence of an Au salt from the auric chloride.
专利号:US-11814399-B1
优先权日:2023-04-07
标 题 :Synthesis of thiazole derivatives
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1371/journal.pone.0218897
摘要:Miller TW, Amason JD, Garcin ED, Lamy L, Dranchak PK, Macarthur R, Braisted J, Rubin JS, Burgess TL, Farrell CL, Roberts DD, Inglese J. Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. PLoS ONE. 2019 Jul 05;14(7):e0218897. doi: 10.1371/journal.pone.0218897.
参考文献:10.1159/000124521
摘要:Blaustein JD, Brown TJ, McElroy JF. Some catecholamine inhibitors do not cause accumulation of nuclear estrogen receptors in rat hypothalamus and anterior pituitary gland. Neuroendocrinology. 1986;43(2):143–9. doi: 10.1159/000124521.
摘要:Journal of Pharmacy and Pharmacology., 27(620), 1975 []
摘要:Proceedings of the Society for Experimental Biology and Medicine., 133(817), 1970 []
摘要:Ulrich, H., Science of Synthesis, (2002) 11, 862.
📝 需求与反馈
尽可能描述清楚需求与问题信息
