CAS: 130722-95-1; 3-(Benzyloxy)-5-Bromopyridine

该化合物是一种多用途溴化丙烯衍生物,在3级具有苯基氧替代成分,该化合物是有机合成中的宝贵中间体,特别是在制药和农用化学研究中.5级的溴原子的存在通过诸如Suzuki或Buchwald-Hartwig等交叉反应可以进一步发挥作用,而苯氧基组则为选择性的去保护或修改提供额外的再活动.其高纯度和稳定性使其适合要求的合成应用.该化合物的界定明确的结构和再活动特征有助于其在生物活性分子的开发中使用,包括潜在的药物候选物和特殊化学物.其合成效用因两个功能组的或多位反应而得到进一步的增强,允许相继转换.

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630120-99-9 1121592-90-2 552331-73-4

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3,5-dibromopyridine sodium phenyl-methanolate benzyl alcohol 5-bromopyridine-3-ol 5-(phenylmethoxy)-pyridin-3-ylamine 5-(benzyloxy)pyridine-3-carbaldehyde 5-bromo-3-(benzyloxy)pyridine N-oxide tert-butyl (1S,4S)-5-[5-(benzyloxy)-3-pyridinyl]-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

合成工艺路线路线简述

    📜3,5-二溴吡啶置于氢化钾,铜,Sodium Hydride体系中,用 N,N-二甲基甲酰胺,异丙醇,Mineral Oil 用作溶剂,化学反应 31.0H,反应生成3-苯甲氧基-5-溴吡啶
    参考文献:Structure-activity Studies Of 7-Heteroaryl-3-Azabicyclo[3.3.1]Non-6-Enes: A Novel Class Of Highly Potent Nicotinic Receptor Ligands
    标题:Structure-activity Studies Of 7-Heteroaryl-3-Azabicyclo[3.3.1]Non-6-Enes: A Novel Class Of Highly Potent Nicotinic Receptor Ligands
    摘要:The Potential For Nicotinic Ligands With Affinity For The Alpha 4 Beta 2 Or Alpha 7 Subtypes To Treat Such Diverse Diseases As Nicotine Addiction,Neuropathic Pain,And Neurodegenerative And Cognitive Disorders Has Been Exhibited Clinically For Several Compounds While Preclinical Activity In Relevant In Vivo Models Has Been Demonstrated For Many More. For Several Therapeutic Programs,We Sought Nicotinic Ligands With Various Combinations Of Affinity And Function Across Both Subtypes,With An Emphasis On Dual Alpha 4 Beta 2-Alpha 7 Ligands,To Explore,The Possibility Of Synergistic Effects. We Report Here The Structure-Activity Relationships (Sar) For A Novel Series Of 7-Heteroaryl-3-Azabicyclo[3.3.1]Non-6-Enes And Characterize Many Of The Analogues For Activity At Multiple Nicotinic Subtypes.
    Doi:10.1021/jm3011299

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    专利信息


    专利号:US-10906888-B2
    优先权日:2016-07-14
    标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
    发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
    权利人:PFIZER
    摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9744252-B2
    优先权日:2011-08-17
    标 题:Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi
    发明人：BERGER MARKUS; KRUGER MARTIN; LOHRKE JESSICA; REINHARDT MICHAEL; SIEBENEICHER HOLGER
    权利人:PIRAMAL IMAGING SA
    摘要:The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein IIb/IIIa antagonists for imaging of thrombi.

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    合成参考文献


    摘要:Wu, S.; Song, H.; Hu, M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 2.
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