CAS: 119356-77-3; (S)-N,N-Dimethyl-3-(Naphthalen-1-Yloxy)-1-Phenylpropan-1-Amine

上下游产品

α-naphthol (S)-(+)-3-(dimethylamino)-3-phenyl-1-propanol Desmethyldapoxetine formaldehyd(S)-2-(dimethyl(3-(naphthalen-1-yloxy)-1-phenylpropyl)ammonio)ethyl (2-hydroxyethyl) phosphate N,N-dimethylamino-3-(naphthyl-1-oxy)-1-phenylprop-1-amine hydr°Chloride

3-氨基-3-苯基-1-丙醇置于potassium Carbonate,溶剂黄146,三乙胺,Sodium Hydroxide体系中,用 乙醇,二氯甲烷,水,丙酮 用作溶剂,化学反应 4.0H,反应生成达泊西汀
参考文献:一种s-达泊西汀及其盐的合成方法
标题:一种s-达泊西汀及其盐的合成方法
摘要:本发明公开了一种s‑达泊西汀的合成方法,包括以下各步骤:(1)将1‑苯基‑3‑(萘基‑1‑氧基)丙胺利用拆分剂进行至少一次拆分,得到拆分混合体系;(2)分离所述拆分混合体系得s‑1‑苯基‑3‑(萘基‑1‑氧基)丙胺,回收母液;(3)将s‑1‑苯基‑3‑(萘基‑1‑氧基)丙胺进行甲基化反应生成s‑达泊西汀.本发明与现有的工业化生产方法相比,在现有技术的基础上,首次对拆分后母液中剩余的中间体(R)‑1‑苯基‑3‑(萘基‑1‑氧基)丙胺进行回收,消旋化后继续用d‑(‑)酒石酸再次拆分,反复循环,这样即提高了产率,也避免了产品的浪费,提高了经济效益.

专利信息

专利号:WO-2011161690-A1
优先权日:2010-06-23
标题:Processes for the preparation of (+)-n,n-dimethyl-2-[1-(naphthalenyloxy) ethyl] benzene methanamine and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; JITHENDER AADEPU; VENUGOPAL BINGI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; JITHENDER AADEPU; VENUGOPAL BINGI
摘要:The present invention relates to processes for the preparation of S(+)-N,N-dimethyl-2-[1-(naphthalenyloxy)ethyl]benzene methanamine and intermediates thereof. More particularly the present invention relates to preparation of the compound 3(S)-(+)-N,N-dimethylamino-3-phenyl propanol useful as intermediate in the synthesis of pharmaceutically active compounds.

专利号:US-8815883-B2
优先权日:2009-11-02
标 题 :Compounds and methods for inhibiting serotonin synthesis
发明人：LANDRY DONALD; DENG SHI-XIAN
权利人:LANDRY DONALD; DENG SHI-XIAN; TRUSTEES OF COLUMBIA UNVIERSITY IN THE CITY OF NEW YORK
摘要:Compounds having the structures below that are TPH1 inhibitors are provided: The compounds are useful of, e.g., to increase bone mass. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis.

专利号:WO-2008084057-A1
优先权日:2007-01-10
标题:Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G
摘要:This invention relates to compounds with a combination of cannabinoid-CB1antagonism and serotonin reuptake inhibition to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders. In particular the invention relates to compoundsof the general formula (I): wherein the symbols have the meanings given in the specification.

专利号:EP-4630405-A1
优先权日:2022-12-06
标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

专利号:US-8138174-B2
优先权日:2007-01-10
标 题:Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; SOLVAY PHARM BV
摘要:Compounds with a combination of cannabinoid CB 1 antagonism and serotonin reuptake inhibition, pharmaceutical compositions containing these compounds, methods for preparing these compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing these compositions are disclosed. Uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders are disclosed. n In at least one embodiment, the invention relates to compounds of the general formula (1): n nwherein the substitutents have the definitions given in the specification.

专利号:WO-2024123815-A1
优先权日:2022-12-06
标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels