📜环戊基溴化镁置于乙醚,Sodium Amide,萘烷体系中,化学反应生成3-环戊基-1-丙炔 参考文献:Gredy,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1934,Vol. 199,P. 1129,1130 标题:Gredy,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1934,Vol. 199,P. 1129,1130
专利号:US-2008086013-A1 优先权日:2006-06-15 标 题:Carbometallation of alkynes and improved synthesis of uniquinones 发明人:LIPSHUTZ BRUCE H 权利人:UNIV CALIFORNIA 摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.
专利号:US-7999090-B2 优先权日:2000-07-07 标 题:Fungal cell wall synthesis gene 发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO 权利人:EISAI R&D MAN CO LTD 摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.
专利号:WO-03061385-A1 优先权日:2002-01-17 标题:Tricyclic nucleoside library compounds, synthesis, and use as antiviral agents 发明人:AN HAOYUN; HONG ZHI; SMITH KENNETH; DING YILI; GIRARDET JEAN-LUC 权利人:RIBAPHARM INC; AN HAOYUN; HONG ZHI; SMITH KENNETH; DING YILI; GIRARDET JEAN-LUC 摘要:Tricyclic nucleoside libraries and library compounds are prepared using combinatorial chemistry and non-combinatorial chemistry methods. Contemplated library compounds are particularly useful in inhibition of viral propagation, and particularly of viral propagation of the HCV virus.
专利号:US-7199105-B2 优先权日:2002-08-15 标 题:Lincomycin derivatives possessing antibacterial activity 发明人:LEWIS JASON G; PATEL DINESH V; ANANDAN SAMPATH KUMAR; GORDEEV MIKHAIL F 权利人:VICURON PHARM INC 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
专利号:US-7164011-B2 优先权日:2002-08-15 标题:Lincomycin derivatives possessing antibacterial activity 发明人:LEWIS JASON; PATEL DINESH V; ANANDAN SAMPATH K; GORDEEV MIKHAIL F 权利人:VICURON PHARM INC 摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
专利号:EP-1399406-B1 优先权日:2001-01-04 标题:Novel estrogen receptor ligands and methods i 发明人:KOEHLER KONRAD; HENSSEN CECILIA; NILSSON MARITA; GILLNER MIKAEL; LIU YE; SANIN ANDREI; WILKENING ROBERT R; RATCLIFFE RONALD W; WENSBO DAVID 权利人:KAROBIO AB; MERCK & CO INC 摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant inventive are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynecomastia, autoimmune disease, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer of the lung, colon, breast, uterus, and prrostate.