CAS: 113873-67-9; Calcineurin Substrate
该化合物是一种用作酶胆碱酯酶基质的乙酸酯,它是钙/卡莫杜林依赖的塞林/硫氨酸磷酸酯,其特征是其特定的氨基酸序列,允许其被氯苯基素识别和脱硫.卡辛基宁的活动在包括T细胞激活和...
- 英文名称Calcineurin Substrate
- 中文名称钙调神经磷酸酶底物
- 其它别名ASP-LEU-ASP-VAL-PRO-ILE-PRO-GLY-ARG-PHE-ASP-ARG-ARG-VAL-SER-VAL-ALA-ALA-GLU; DLDVPIPGRFDRRVSVAAE; CALCINEURIN (PP2B) SUBSTRATE [DLDVPIPGRFDRRVSSVAAE], NON-PHOSPHORYLATED; CALCINEURIN SUBSTRATE; H-ASP-LEU-ASP-VAL-PRO-ILE-PRO-GLY-ARG-PHE-ASP-ARG-ARG-VAL-SER-VAL-ALA-ALA-GLU-OH; [ALA-97]-RII (81-99); Calcineurin (PP2B) Substrate [DLDVPIPGRFDRRVSVAAE], Non-Phosphorylated
- CAS编号113873-67-9
- MFCD编号:MFCD00236901
- 分子式:C92H150N28O29分子量:2112.35
- 产品CID: 171120
- 产品分类生物化工 → 多肽
物理性质
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
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专利信息
专利号:US-2024391961-A1
优先权日:2021-08-25
标题:Autonomous organisms for synthesis of permanently phosphorylated proteins
发明人：COOLEY RICHARD B; MEHL RYAN A; ZHU PHILLIP
权利人:UNIV OREGON STATE
摘要:Embodiments of the present disclosure provide compositions and methods for biosynthesizing a stable, functional mimic of phosphoserine. The compositions and methods described herein genetically program a host cell to express a biosynthetic pathway that can synthesize the amino acid, 2-amino-4-phosphobobutyric acid, that is a non-hydrolyzable phosphoserine (nhpSer) because it contains a carbon-phosphorus, e.g., phosphonate, bond. In one embodiment the genetically programed cells express the enzymes of a pathway from a Streptomyces bacterium . In some embodiments, nhpSer is translationally incorporated into protein of interest at one or more programmed UAG amber codons using Genetic Code Expansion (GCE) technology.
