CAS: 112398-08-0; 1-Cyclopropyl-6-Fluoro-7-((1S,4S)-5-Methyl-2,5-Diazabicyclo[2.2.1]Heptan-2-yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid

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CAS号93107-30-3 1-环丙基-6,7-二氟-1,...

📜1-环丙基-6,7-二氟-1,4-二氢-4-氧喹啉-3-羧酸,2-Methyl-2,5-Diazabicyclo[2.2.1]Heptane Dihydrochloride置于吡啶,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,化学反应 2.0H,以81%的收率获得达诺沙星
参考文献:7-二氮杂双环烷基喹诺酮类化合物的合成与构效关系,包括一种新的兽药喹诺酮类抗菌药物达诺沙星.
标题:7-二氮杂双环烷基喹诺酮类化合物的合成与构效关系,包括一种新的兽药喹诺酮类抗菌药物达诺沙星.
摘要:一系列被各种c8(h,F,Cl,N)和n1(乙基,环丙基,乙烯基,2-氟乙基,4-氟苯基,2,4-二氟苯基)取代基取代的新颖的6-氟-7-二氮杂双环烷基喹诺酮羧酸,以及9-氟-10-二氮杂双环烷基吡啶并苯并恶嗪羧酸,并针对一系列重要的兽医病原菌进行了抗菌活性评估.在7位(苯并恶嗪10位)研究的二氮杂双环烷基侧链包括(1S,4S)-5-甲基-2,5-二氮杂双环[2.2.1]庚烷(2),(1S,4S)-2,5-二氮杂双环[2.2.1]庚烷(3),(1R,4R)-5-甲基-2,5-二氮杂双环[2.2.1]庚烷(4),8-甲基-3,8-二氮杂双环[3.2. 1]辛烷(5),9-甲基-3,9-二氮杂双环[4.2.1]壬烷(6),1,4-二氮杂双环[3.2.2]壬烷(7),1,4-二氮杂双环[3.3.1] ]壬烷(8)和9-甲基-3,9-二氮杂双环[3.3.1]壬烷(9).在这些侧链中,体外效能不是
Doi:10.1021/jm00082A001

专利信息

专利号:US-11274081-B2
优先权日:2016-05-30
标 题:Process for the synthesis of ivacaftor
发明人：REDDY DUMBALA SRINIVASA; KULKARNI AMOL ARVIND; NATARAJAN VASUDEVAN; SHARMA MRITYUNJAY KESHAVPRASAD
权利人:COUNCIL SCIENT IND RES
摘要:The present disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The present invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.

专利号:US-11332444-B2
优先权日:2018-04-25
标题:Method for the hydrolysis of quinolonecarboxylic esters
发明人：FEY PETER; BERWE MATHIAS; WIRTHS Joerg; WISCHNAT RALF; LONGERICH MARKUS; DIETZEL ANTJE
权利人:BAYER ANIMAL HEALTH GMBH
摘要:Quinolonecarboxylic esters of the general formula (II) are hydrolyzed to quinolonecarboxylic acids of the general formula (I):The method comprises the step A):A) reacting compounds of the formula (II) with a mixture comprising acetic acid, sulfuric acid and waterIn step A), ≥30 to ≤40 mol of acetic acid, ≥0.3 to ≤1 mol of sulfuric acid and ≥0.9 to ≤2.5 mol of water are used per mole of compounds of the formula (II). The method is particularly suitable for the synthesis of the intermediate (I) in the synthesis of pradofloxacin.

专利号:US-8093381-B2
优先权日:2007-05-24
标题:Method of synthesis of fluoroquinolones
发明人：BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS
权利人:BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS; BIOCODEX
摘要:The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): n nin which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and X are as defined in Claim 1.

专利号:US-2009054643-A1
优先权日:2007-05-24
标 题:Novel method of synthesis of fluoroquinolones

专利号:CN-102962041-B
优先权日:2012-11-07
标题 :Preparation method and application of microwave-assisted synthesis of chlorine-doped surface molecularly imprinted photocatalysts

专利号:CN-102962041-A
优先权日:2012-11-07
标 题:Preparation method and application of microwave-assisted synthesis of chlorine-doped surface molecularly imprinted photocatalysts