CAS: 98-58-8; 4-Bromobenzenesulfonyl Chloride

上下游产品

bromobenzene (4-bromophenyl)diazonium chloride 1.4-dibromobenzene (4-bromophenyl)(methoxymethyl)sulfane 4-bromo-N-(thiazol-2-yl)benzene sulfonamide 4-bromo-N-pyrimidin-2-ylbenzenesulfonamide 4-bromo-benzenesulfonic acid-(4-methyl-thiazol-2-ylamide) 4-bromo-benzenesulfonic acid-[1]naphthylamide

4-溴苯磺酸置于氯化亚砜体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.0H,反应生成 4-溴苯磺酰氯
参考文献:高效 Denv Ns2B-Ns3 共价抑制剂的鉴定和计算机结合研究
标题:高效 Denv Ns2B-Ns3 共价抑制剂的鉴定和计算机结合研究
摘要:登革热病毒(denv)是一种节肢动物传播的黄病毒,在过去的几十年里发展迅速,成为世界上分布最广的虫媒病毒.ns2B-Ns3 在病毒复制和病毒蛋白成熟中的重要作用使其成为抗 Denv 药物发现的最有希望的靶标.在目前的工作中,通过对已发表的共价抑制剂1 (Ic 50 = 500 Nm,K Inac / K I = 156.1 M-1 S-1),然后进行体外测定.通过共价对接和分子动力学模拟进一步全面的结构-活性关系分析提供了对靶向 Ns2B-Ns3 的共价抑制剂结合模式的信息理解.
DOI:10.1021/acsmedchemlett.1C00653

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-7199257-B1
优先权日:1999-06-10
标题 :Process for the synthesis of N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide
发明人：SOEROES BELA; TUBA ZOLTAN; GALIK GYOERGY; BOR ADAM; DEMETER ADAM; TRISCHLER FERENC; HORVATH JANOS; BRLIK JANOS
权利人:RICHTER GEDEON VEGYESZET
摘要:A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis.

专利号:US-2025188046-A1
优先权日:2023-12-08
标题:Ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent sufex connections via lithiated chemistry
发明人：KIM DONG-PYO; KANG JI-HO
权利人:POSTECH RES & BUSINESS DEV FOUND
摘要:Disclosed are ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent SuFEx connections via lithiated chemistry. In detail, a method of synthesizing an ortho-functionalized benzenesulfonyl fluoride derivative, the method comprises (a) reacting a benzenesulfonyl fluoride derivative represented by structural formula 1 with an organolithium represented by structural formula 2, thus synthesizing an intermediate represented by structural formula 3 in reaction scheme 1 and (b) reacting the intermediate with an electrophile, thus synthesizing a compound represented by structural formula 4 or a compound represented by structural formula 4′. The present disclosure enables the synthesis of several functionalized sulfonyl fluorides within a few seconds under mild temperature conditions in addition to the chemistry of Sulfonyl Fluoride Exchange (SuFEx), which is a next-generation click chemistry, so that sulfonyl fluoride, the main reactant of the SuFEx reaction, can be efficiently secured.

专利号:US-4287123-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R is a readily removable carboxyl protecting group; and is a readily removable acyl group.

专利号:US-4282148-A
优先权日:1980-01-14
标 题:Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-4414155-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.