CAS: 951-78-0; 1-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyrimidine-2,4(1H,3H)-Dione

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尿嘧啶核苷 以60%的收率获得产物2-脱氧尿苷
参考文献:同位素富集的嘧啶脱氧核苷氧化损伤产物的合成与表征.
标题:同位素富集的嘧啶脱氧核苷氧化损伤产物的合成与表征.
摘要:对dna的氧化损伤是基因组不稳定的公认来源.在本文中,我们描述了几种富含稳定同位素的嘧啶脱氧核苷氧化损伤产物的合成和表征.这些产物包括5-(羟甲基)尿嘧啶,5-甲酰基尿嘧啶,5-羟尿嘧啶,5-(羟甲基)胞嘧啶,5-甲酰基胞嘧啶和5-羟胞嘧啶的2'-脱氧核苷衍生物.常见的前体是2'-脱氧-2"-氘[1,3-15N]尿苷.在官能团转化过程中会添加其他稳定的同位素.这些衍生物的表征包括质谱以及1H和15N NMR光谱.质子和氮NMR此处报道的研究可以检查修饰对糖构象和互变异构平衡的影响,
DOI:10.1021/tx970186O

专利信息

专利号:US-5204456-A
优先权日:1986-04-08
标题:Derivatives of nucleosides and their use for the synthesis of oligonucleotides
发明人：MOLKO DIDIER; SCHULHOF JEAN-CLAUDE; TEOULE ROBERT
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: (I) in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group with R1 representing a hydrogen atom or a alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical R4 represents a hydrogen atom, the radical of formula: or a radical suitable for the synthesis of polynucelotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.

专利号:WO-9640901-A1
优先权日:1995-06-07
标题 :Template and primer based synthesis of enzymatically cleavable oligonucleotides
发明人：DATTAGUPTA NANIBHUSHAN; KACIAN DANIEL LOUIS; LACKEY DAVID BRUCE
权利人:GEN PROBE INC
摘要:The present invention relates to methods of enzymatically synthesizing chirally pure oligonucleotides. In particular, it relates to methods of enzymatically synthesizing oligonucleotides using optionally digestible templates which are capable of directing the synthesis of an oligonucleotide product which can optionally be cleaved into two or more individual oligonucleotides, optionally using 3'-ribonucleotide primers. In this manner, more than one oligonucleotide having the same or different length and/or sequence can be simultaneously synthesized. The oligonucleotides optionally have at least one phosphorothioate linkage, and contain certain restriction endonuclease recognition sites herein identified as cleavable within phosphorothioate oligonucleotides, thus facilitating the separation and purification of the oligonucleotides after synthesis.

专利号:US-2024052391-A1
优先权日:2020-10-29
标 题 :Enzymatic Synthesis of Polynucleotide Probes
发明人：GODRON XAVIER; NIYOMCHON SUPAPORN; CHAMPION ELISE
权利人:DNA SCRIPT
摘要:The present invention is directed to methods and kits for enzymatic synthesis of labeled polynucleotide probes using template-free DNA polymerases.

专利号:US-7691635-B2
优先权日:2004-03-26
标题 :Labeling reagents, methods for the synthesis of such reagents and methods for the detection of biological molecules
发明人：LAAYOUN ALI; BERNAL-MENDEZ ELOY
权利人:BIOMERIEUX SA
摘要:The present invention relates to a temperature-stable labeling reagent of formula (0): n nin which:n R 1 represents H or an alkyl, aryl or substituted aryl group, R 2 represents a detectable marker or at least two detectable markers interlinked by at least one multimeric structure, L is a linker arm comprising a linear chain of at least two covalent bonds and n is an integer equal to 0 or 1, R 3 and R 4 represent, independently of one another: H, NO 2 , Cl, Br, F, I, R 2 -(L) n -Y—X—, OR, SR, NR 2 , R, NHCOR, CONHR, COOR, —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 3 —CH 2 —NH—R 2 , —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 4 —CH 2 —NH—R 2 with R=alkyl or aryl, A is a linker arm comprising at least one covalent double bond enabling the conjugation of the diazo function with the aromatic ring and u is an integer between 0 and 2, preferably 0 or 1, —Y—X— represents —CONH—, —NHCO—, —CH 2 O—, —CH 2 S—, —Z— represents —NH—, —NHCO—, —CONH— or —O—, m is an integer between 1 and 10, preferably between 1 and 3, and p is an integer between 1 and 10, preferably between 1 and 3. n The present invention also describes a method for the synthesis of said labels and also applications for the labeling of biological molecules, in particular of nucleic acids, with a labeling reagent bearing the diazomethyl function. n The invention is particularly suitable for use in the field of diagnostics.

专利号:EP-1992632-A1
优先权日:2007-05-12
标题 :Method for the synthesis of cyclouridine
发明人：MOCIARDINI SIMONE; COLOMBO PAOLO
权利人:EXPLORA LAB SA
摘要:Method for the synthesis of possibly substituted cyclic derivatives of uridine, of formula (II)n nwherein R is chosen in the group that comprises: hydrogen, halogen and C 1-4 alkyl, the method comprising the step of reacting a possibly substituted uridine of formula (III)n nwherein R has the same meanings as in formula (II), and glycerol carbonate in the presence of an alkaline carbonate at a temperature of 70°C-130°C.

专利号:US-8350022-B2
优先权日:2008-04-04
标题 :Method for the stereoselective synthesis of phosphorus compounds
发明人：MEIER CHRIS; THOMANN JENS O
权利人:UNIV HAMBURG; MEIER CHRIS; THOMANN JENS O
摘要:The present invention relates to a method for stereoselective synthesis of phosphorus compounds, whereby in the first reaction step a chiral auxiliary on the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride is covalently bonded, the product from the first reaction step is reacted in the following step with an alcohol, thiol, or amine as the nucleophile in the presence of a base, and in the last step the chiral auxiliary is displaced from the product of the following step by a nucleophile.