CAS: 938-73-8; 2-Ethoxybenzamide

该化合物是一种有机化合物,其特点是芳香结构,其特点是以苯环替换成一个环状苯,并有一个氨化功能组,其分子式为C10H13NO2,表明碳,氢,氮和氧原子的存在.乙氧基组(-OCH2CH3)有助于其溶解性,使其在有机溶剂中比在水中更容易溶解.氨化功能组(-CONH2)以其参与氢结合的能力而著称,它能够影响化合物的沸点和熔点.2-乙氧苯并二苯基在室内温度下一般是白色的,在标准条件下可能具有中度稳定性.它经常用于有机合成,并可作为生产药品或农用化学剂的中间体.在处理和储存时,应参考安全数据,如同任何化学物质一样,以确保由于潜在的毒性或再活性而采取适当的预防措施.

结构式图片

物理性质

MSDS等安全信息

上下游产品

2-Ethoxy-N-Methoxybenzamide 1197680-14-0
2-(乙烯基氧基)苯甲酰胺 2-Vinyloxybenzamide 88576-66-3
2-乙氧基苯甲醛 2-Ethoxylbenzaldehyde 613-69-4
水杨酰胺 Salicylamide 65-45-2
2-乙氧基苯甲酸 2-Ethoxybenzoic Acid 134-11-2
水杨酰肼 2-Hydroxybenzoylhydrazine 936-02-7
乙氧基苯乙酮 1-(2-Ethoxyphenyl)Ethanone 2142-67-8
邻乙氧基苯甲酰氯 2-Ethoxybenzoyl Chloride 42926-52-3
2-乙氧基苯甲酸甲酯 Methyl 2-Ethoxybenzoate 3686-55-3

合成工艺路线路线简述

  • 合成目标产物 2-Ethoxybenzamide 主要起始原料 2-Ethoxybenzonitrile
  • 6609-57-0 = 938-73-8
    反应条件:1.1 Catalysts: 2,2′-Bipyridine,Palladium Diacetate Solvents: 1,4-Dioxane,Water; 24 H,90 °C
    标题:A Selective Hydration Of Nitriles Catalyzed By A Pd(Oac)2-Based System In Water
    作者:Sanz Sharley,Daniel D.; Williams,Jonathan M. J.
    参考文献:Tetrahedron Letters 日期:2017 卷标:58(43) 页码:4090-4093]

    37806-29-4 = 938-73-8
    反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: 2506117-64-0 Solvents: Dimethyl Sulfoxide; 48 H,80 °C
    标题:A New Facet Of Amide Synthesis By Tandem Acceptorless Dehydrogenation Of Amines And Oxygen Transfer Of Dmso
    作者:Nie,Xufeng; Wang,Mei; Fu,Yihua; Xu,Jiaqi; Zheng,Xueli; Et Al
    参考文献:Journal Of Catalysis 日期:2023 卷标:417 页码:153-163]

    445-28-3 = 938-73-8
    反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Cupric Acetate Solvents: Ethanol; 10 Min,180 Psi,120 °C
    标题:Copper-Catalyzed Self-Condensation Of Benzamide: Domino Reactions Towards Quinazolinones
    作者:Sayyad,Nisar; Cele,Zamani; Aleti,Rajeshwar Reddy; Bera,Milan; Cherukupalli,Srinivasulu; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2018 卷标:2018(39) 页码:5382-5388]

    134-11-2 = 938-73-8
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide; 24 H,Rt1.2 Reagents: Ammonia Solvents: Chloroform,Water; -10 °C
    标题:Hofmann Rearrangement Of Carboxamides Mediated By N-Bromoacetamide
    作者:Jevtic,Ivana I.; Dosen-Micovic,Ljiljana; Ivanovic,Evica R.; Ivanovic,Milovan D.
    参考文献:Synthesis 日期:2016 卷标:48(10) 页码:1550-1560]

    666213-87-2 = 938-73-8 [标题:Reaction Conditions
    标题:Auxiliary-Directed Etherification Of Sp2 C-H Bonds Under Heterogeneous Metal-Organic Framework Catalysis: Synthesis Of Ethenzamide
    作者:Tran,Chau B.; Duong,Xuan N. T.; Lu,Huy D.; Cao,Thu T. V.; Truong,Thanh
    参考文献:Rsc Advances 日期:2018 卷标:8(5) 页码:2829-2836]

    613-69-4 = 938-73-8
    反应条件:1.1 Reagents: Saccharin Catalysts: Titanium Superoxide (Ti(O2)2) Solvents: 1,4-Dioxane,Decane; Rt; 1 H,Rt -> 90 °C
    标题:Ti-Superoxide Catalyzed Oxidative Amidation Of Aldehydes With Saccharin As Nitrogen Source: Synthesis Of Primary Amides
    作者:Kamble,Rohit B.; Mane,Kishor D.; Rupanawar,Bapurao D.; Korekar,Pranjal; Sudalai,A.; Et Al
    参考文献:Rsc Advances 日期:2020 卷标:10(2) 页码:724-728]

    1197680-14-0 = 938-73-8
    反应条件:1.1 Catalysts: Bis(Dichloro(η6-P-Cymene)Ruthenium) Solvents: Water; 24 H,80 °C
    标题:Method For Preparation Of Primary And Secondary Amide Compounds From N-Substituted Amide Compounds Adopting Dichloro(P-Cymene)Ruthenium (Ii) Dimer Complex As Catalyst
    参考文献:China]

    6609-57-0 = 938-73-8
    反应条件:1.1 Reagents: Water Catalysts: 2853616-75-6 Solvents: Isopropanol; 2 H,80 °C
    标题:Hydration Of Nitriles Catalyzed By Ruthenium Complexes: Role Of Dihydrogen Bonding Interactions In Promoting Base-Free Catalysis
    作者:Yadav,Samanta; Gupta,Rajeev
    参考文献:Inorganic Chemistry 日期:2022 卷标:61(39) 页码:15463-15474]

    3019-71-4 + 583-19-7 = 938-73-8
    反应条件:1.1 Reagents: Magnesium,Lithium Chloride Solvents: Tetrahydrofuran; 0 °C; 1 H,0 °C1.2 Reagents: Zinc Chloride Solvents: Tetrahydrofuran; 25 °C; 25 °C -> -20 °C1.3 Solvents: Tetrahydrofuran; -20 °C; 5 Min,-20 °C; -20 °C -> 25 °C; 2 H,25 °C1.4 Reagents: Potassium Carbonate Solvents: Methanol; 25 °C; 12 H,25 °C
    标题:Preparation Of Primary Amides From Functionalized Organozinc Halides
    作者:Schade,Matthias A.; Manolikakes,Georg; Knochel,Paul
    参考文献:Organic Letters 日期:2010 卷标:12(16) 页码:3648-3650]

    65-45-2 = 938-73-8
    反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Benzyltriethylammonium Chloride Solvents: Ethanol
    标题:Catalytic Synthesis Of Ethenzamide
    作者:Li,Ji-Peng; He,Zi-Yi
    参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2000 卷标:31(2)]

    1197680-14-0 = 938-73-8
    反应条件:1.1 Reagents: Formic Acid,Triethylamine Catalysts: Bis(Dichloro(η6-P-Cymene)Ruthenium) Solvents: Water; 12 H,100 °C1.2 Reagents: Ammonium Chloride Solvents: Water
    标题:Ruthenium(Ii)-Catalyzed Reductive N-O Bond Cleavage Of N-Or (R = H,Alkyl,Or Acyl) Substituted Amides And Sulfonamides
    作者:You,Tingjie; Zhang,Maosheng; Chen,Jianhui; Liu,Hongmei; Xia,Yuanzhi
    参考文献:Organic Chemistry Frontiers 日期:2021 卷标:8(1) 页码:112-119]

    6609-57-0 = 938-73-8
    反应条件:1.1 Reagents: Potassium Tert-Butoxide Solvents: Toluene; 5 H,60 °C
    标题:Transition-Metal-Free Hydration Of Nitriles Using Potassium Tert-Butoxide Under Anhydrous Conditions
    作者:Midya,Ganesh Chandra; Kapat,Ajoy; Maiti,Subhadip; Dash,Jyotirmayee
    参考文献:Journal Of Organic Chemistry 日期:2015 卷标:80(8) 页码:4148-4151]

    65-45-2 = 938-73-8
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Potassium Iodide Solvents: Acetone; 10 H,100 °C
    标题:Studies On Improving The Process Yield And Purity Of O-Ethoxybenzamide
    作者:Falkowski,Cezariusz; Glazer,Krzysztof; Gaca,Jerzy
    参考文献:Przemysl Chemiczny 日期:2006 卷标:85(8-9) 页码:584-586]

    65-45-2 = 938-73-8
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Potassium Iodide Solvents: Acetone; Rt -> 100 °C; 100 °C
    标题:Process Of Preparing O-Ethoxybenzamide
    参考文献:Poland]

    613-69-4 = 938-73-8
    反应条件:1.1 Reagents: Cesium Carbonate,Hydroxyamine Hydrochloride Catalysts: Palladium Diacetate Solvents: Dimethyl Sulfoxide,Water; 19 H,100 °C; 100 °C -> Rt
    标题:Palladium-Catalyzed One-Pot Conversion Of Aldehydes To Amides
    作者:Ali,Ashif Md.; Punniyamurthy,Tharmalingam
    参考文献:Advanced Synthesis & Catalysis 日期:2010 卷标:352 页码:288-292]

    6609-57-0 = 938-73-8
    反应条件:1.1 Reagents: Diisopropylethylamine,Dipotassium Phosphate,Oxygen Catalysts: Tris(2,2′-Bipyridyl)Dichlororuthenium(Ii) Hexahydrate Solvents: Methanol,Acetonitrile,Water; 20 H,1 Atm,Rt
    标题:Green Method And System For Preparation Of Amide Compounds From Nitrile Compounds
    参考文献:China]

    6609-57-0 = 938-73-8
    反应条件:1.1 Reagents: Potassium Hydroxide,Oxygen Catalysts: Gallic Acid Solvents: Ethanol,Water; 30 H,Rt1.2 Reagents: Ammonium Chloride Solvents: Water; Rt
    标题:Efficient Hydration Of Nitriles Promoted By Gallic Acid Derived From Renewable Bioresources
    作者:Deng,Tao; Wang,Cheng-Zhang
    参考文献:Chemcatchem 日期:2017 卷标:9(7) 页码:1349-1353]

    90843-12-2 = 938-73-8
    反应条件:1.1 Reagents: Ammonia Catalysts: Iodine Solvents: Dimethyl Sulfoxide,Water; 3 H,Rt1.2 Reagents: Sodium Thiosulfate Solvents: Water; Rt
    标题:Visible Light-Induced Iodine-Catalyzed Transformation Of Terminal Alkynes To Primary Amides Via Cc Bond Cleavage Under Aqueous Conditions
    作者:Dighe,Shashikant U.; Batra,Sanjay
    参考文献:Advanced Synthesis & Catalysis 日期:2016 卷标:358(3) 页码:500-505]

    445-28-3 = 938-73-8
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Dimethyl Sulfoxide; 16 H,Rt
    标题:Base-Promoted Nucleophilic Fluoroarenes Substitution Of C-F Bonds
    作者:Su,Ji; Chen,Qian; Lu,Le; Ma,Yuan; Auyoung,George Hong Lok; Et Al
    参考文献:Tetrahedron 日期:2018 卷标:74(2) 页码:303-307]

    613-69-4 = 938-73-8
    反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide,Ammonia Catalysts: Tetrabutylammonium Iodide Solvents: Acetonitrile; 8 H,80 °C
    标题:Highly Efficient Dehydrogenative Cross-Coupling Of Aldehydes With Amines And Alcohols
    作者:Deshidi,Ramesh; Rizvi,Masood Ahmad; Shah,Bhahwal Ali
    参考文献:Rsc Advances 日期:2015 卷标:5(110) 页码:90521-90524
📜2-乙氧基苯甲酸甲酯置于ammonium Hydroxide体系中,化学反应生成 2-乙氧基苯甲酰胺
参考文献:Limpricht,Justus Liebigs Annalen Der Chemie,1856,Vol. 98,P. 258
标题:Limpricht,Justus Liebigs Annalen Der Chemie,1856,Vol. 98,P. 258

海关参考信息

专利信息


专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:US-2021386068-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
发明人：KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.

专利号:US-2021352899-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
发明人：KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.

专利号:US-2015352230-A1
优先权日:2013-01-11
标 题:Synthesis and isolation of dendrimer based imaging systems
发明人：MULLEN DOUGLAS GURNETT; BAKER JR JAMES R; BANASZAK HOLL MARK M; HUANG BAOHUA; DOUGHERTY CASEY; BALL JACK
权利人:UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of antibodies conjugated with modular dendrimer nanoparticles. In particular, the present invention is directed to antibodies conjugated with novel modular dendrimer nanoparticles having precise numbers of imaging agents, methods of synthesizing the same, compositions comprising such antibodies conjugated with such modular dendrimer nanoparticles, as well as systems and methods utilizing the conjugates (e.g., in imaging settings) (e.g., in diagnostic and/or therapeutic settings) (e.g., for the delivery of therapeutics, imaging, and/or targeting agents).

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主要参考文献


1: Przybyłek M, Ziółkowska D, Mroczyńska K, Cysewski P. Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids. Eur J Pharm Sci. 2016 Mar 31;85:132-40. doi: 10.1016/j.ejps.2016.02.010. Epub 2016 Feb 17. doi: 10.1107/S1600536810012407.
5: Fukunaka T, Golman B, Shinohara K. Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling. Int J Pharm. 2006 Mar 27;311(1-2):89-96. Epub 2006 Jan 20. Japanese. doi: 10.1016/j.ijpharm.2015.02.026. Epub 2015 Feb 11.

合成参考文献


参考文献:10.1107/s1600536811009536
摘要:Khan IU, Khan MH, Arshad MN, Akkurt M. 2-(4-Chloro-benzamido)-acetic acid. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o916.
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