CAS: 844501-00-4; (1-(Tert-Butoxycarbonyl)-1,2,3,6-Tetrahydropyridin-4-yl)Boronic Acid
- 英文名称(1-(Tert-Butoxycarbonyl)-1,2,3,6-Tetrahydropyridin-4-yl)Boronic Acid
- 中文名称[1-(叔丁氧基羰基)-1,2,3,6-四氢吡啶-4-基]硼酸
- IUPAC名称(1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)boronic acid
- 其它别名(1-{[(2-甲基-2-丙基)氧基]羰基}-1,2,3,6-四氢-4-吡啶基)硼酸; N-Boc-1,2,3,6-Tetrahydropyridin-4-Ylboronic Acid
- CAS编号844501-00-4
- MFCD编号:MFCD09997795
- 分子式:C10H18BNO4分子量:227.07
- 产品CID: 1832794
- 产品分类有机原料→分子砌块→脂肪杂环类化合物→哌啶类化合物
相似化合物
286961-14-6 1451153-83-5 2746407-88-3物理性质
MSDS等安全信息
上下游产品
CAS号375853-82-0 1,2,3,6-四氢吡啶-4-...合成工艺路线路线简述
- 286961-14-6 = 844501-00-4
反应条件:1.1 Reagents: Ammonium Acetate,Sodium Periodate Solvents: Acetone,Water; 24 H,Rt
标题:Potent And Selective Human Neuronal Nitric Oxide Synthase Inhibition By Optimization Of The 2-Aminopyridine-Based Scaffold With A Pyridine Linker
作者:Wang,Heng-Yen; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2016 卷标:59(10) 页码:4913-4925]
286961-14-6 = 844501-00-4 [标题:Reaction Conditions
标题:Development And Investigation Of A Site Selective Palladium-Catalyzed 1,4-Difunctionalization Of Isoprene Using Pyridine-Oxazoline Ligands
作者:Mccammant,Matthew S.; Et Al
参考文献:Chemical Science 日期:2015 卷标:6(2) 页码:1355-1361
📜N-Boc-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯置于sodium Periodate,Ammonium Acetate体系中,用 水,丙酮 作为反应溶剂,化学反应 24.0H,反应生成 [1-(叔丁氧基羰基)-1,2,3,6-四氢吡啶-4-基]硼酸
参考文献:有力和选择性的人类神经元一氧化氮合酶抑制的优化基于2-氨基吡啶的吡啶连接基的支架.
标题:有力和选择性的人类神经元一氧化氮合酶抑制的优化基于2-氨基吡啶的吡啶连接基的支架.
摘要:神经元一氧化氮合酶(nnos)是治疗各种神经退行性疾病的重要治疗靶标.设计nnos抑制剂的主要挑战在于对人类的效力以及对其他nos同工型的选择性.在这里,我们报告基于2-氨基吡啶骨架与中央吡啶连接基的有效和选择性人类nnos抑制剂.化合物14J是这项研究中最有希望的抑制剂,对大鼠nnos(k I = 16 Nm)具有828倍n / E和118倍n / I选择性,对人nnos的k I值为13 Nm,具有出色的药效.具有1761倍的人类n / E选择性.化合物14J 尽管它对caco-2的通透性很小甚至没有,但在人肝微粒体中也显示出非常好的代谢稳定性,血浆蛋白结合率低,与细胞色素p450(cyps)的结合力最小.
DOI:10.1021/acs.Jmedchem.6B00273
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
