CAS: 77326-36-4; 2-Amino-6-Fluorobenzonitrile

上下游产品

CAS号1897-52-5 2,6-二氟苯腈 | CAS号1194-65-6 2,6-二氯苯腈 | CAS号372-19-0 3-氟苯胺 | CAS号545-06-2 三氯乙腈 | CAS号405169-16-6 多韦替尼 | CAS号434-76-4 2-氨基-6-氟苯甲酸 | CAS号192570-33-5 5-氟喹唑啉-2,4(1H,3H)-二酮 | CAS号86505-94-4 2-氨基-6-氟苯甲酸甲酯 | CAS号79544-27-7 2-溴-6-氟苯腈 | CAS号79544-29-9 2-氟-6-碘苯甲腈 | CAS号65610-13-1 3-氟邻苯二腈 | CAS号115643-59-9 2-氨基-6-氟苯甲酰胺 | CAS号119584-70-2 2,4-二氨基-5-氟喹唑啉 | CAS号143306-27-8 2-氟-6-硝基苯腈

敌草腈置于potassium Fluoride,18-冠醚-6,氨体系中,化学反应 13.0H,反应生成 2-氨基-6-氟苯腈
参考文献:Changes In The Activity And Selectivity Of Herbicides By Selective Fluorine Substitution,Taking Bentranil And Classic® Analogues As Examples
标题:Changes In The Activity And Selectivity Of Herbicides By Selective Fluorine Substitution,Taking Bentranil And Classic® Analogues As Examples
摘要:将氟原子引入2-苯基-4H-3,1-苯并噁嗪-4-酮(苯噁嗪)中,在某些情况下会对其除草性能产生巨大影响,5-氟-2-苯基-4H-3,1-苯并噁嗪-4-酮('氟苯噁嗪')被发现是最活性的化合物.它可以由2-氨基-6-氟苯甲酸制备,或通过直接卤素交换5-氯-2-苯基-4H-3,1-苯并噁嗪-4-酮来制备.后一种反应在试验规模上进行了研究,包括高温(350oc)下无溶剂的氟化钾卤素交换.当作作为反应溶剂使用戊磺醚时,220oc时可能发生的一个副反应--部分分解为二苯醚--可以通过添加少量自由基清除剂来防止.通过侧链氯化适当的甲基磺基苯甲酸前体和卤素交换获得了其他具有伪卤素取代的中间体.'氟苯噁嗪'在水稻,谷物和玉米上表现出非常好的广谱活性和选择性.在第二个案例研究中,上述氟代蒽醌酸也被发现适合用于通过其苯胺功能的meerwein反应合成除草磺酰脲(su)化合物.2-[(4-氯-6-甲氧基-2-嘧啶基)氨基]羰基]氨基]磺酰]-6-氟苯甲酸甲酯是与玉米兼容的su的一个例子,而未取代的classic®类似物则不具有选择性.
DOI:10.2533/000942904777678226

专利信息

专利号:CN-101223157-B
优先权日:2005-05-17
标 题 :Process for the synthesis of heterocyclic compounds

专利号:EP-1370553-B1
优先权日:2001-03-23
标 题 :Rho-kinase inhibitors
发明人：NAGARATHNAM DHANAPALAN; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; KHIRE UDAY; WANG CHUNGUANG; HART BARRY; BOYER STEPHEN; WEBER OLAF; LYNCH MARK; BANKSTON DONALD
权利人:BAYER AG
摘要:Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.