CAS: 737000-76-9; (3,5-Difluoro-2-Methoxyphenyl)Boronic Acid

上下游产品

CAS号202865-59-6 2-溴-4,6-二氟苯甲醚 | CAS号1150114-51-4 3,5-二氟-2-羟基苯硼酸

📜2-溴-4,6-二氟苯甲醚置于正丁基锂,硼酸三异丙酯,盐酸体系中,用 四氢呋喃,乙醚 作为反应溶剂,化学反应 0.53H,以228 Mg的收率获得产物3,5-二氟-2-甲氧基苯硼酸
参考文献:Synthetic Chemistry-Led Creation Of A Difluorinated Biaryl Ether Non-Nucleoside Reverse Transcriptase Inhibitor
标题:Synthetic Chemistry-Led Creation Of A Difluorinated Biaryl Ether Non-Nucleoside Reverse Transcriptase Inhibitor
摘要:在新开发的一系列含氟联苯醚结构的非核苷逆转录酶抑制剂中,我们偶然发现了衍生物20,它对野生型及临床相关突变型的逆转录酶均表现出卓越的抑制效力.
DOI:10.1039/b714091F

专利信息

专利号:US-9951062-B2
优先权日:2012-12-14
标 题 :Substituted 1 H-pyrrolo [2, 3-b] pyridine and 1 H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANIPISETTY VENU BABU; TALLURI SURESHKUMAR; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:Compounds according to Formulas I, IA or IB: n nto pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and/or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.

专利号:US-9834551-B2
优先权日:2013-04-18
标 题 :Substituted pyrrolo[2,3-b]pyrazines and substituted pyrazolo[3,4-b]pyridines as ITK and JAK kinase inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANGIREDDY PARAMAREDDY; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:The present invention relates to compounds described by Formula I: n nsalts thereof, their synthesis, and their use as ITK and JAK3 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such disease associated with abnormal cell growth such as autoimmune, inflammation, rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's, metabolic and cancer diseases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions and processes for preparing the compounds of the invention.