CAS: 61798-24-1; N1,N2-Dimethylcyclohexane-1,2-Diamine

上下游产品

CAS号21436-03-3 (1S,2S)-(+)-1,2-环己二胺 | CAS号51066-08-1 7-methyl-7-azab... | CAS号61798-24-1 N,N'-二甲基-1,2-环己二胺 | CAS号286-20-4 环氧环己烷 | CAS号20431-81-6 rel-(1R,2R)-2-(... | CAS号122743-11-7 N,N'-((1S,2S)-c... | CAS号61798-24-1 N,N'-二甲基-1,2-环己二胺 | CAS号68737-65-5 (1|R|,2|R|)-(-)... | CAS号16096-33-6 1-苯基吲哚 | CAS号883-39-6 1-苯基-1H-苯并[d][1... | CAS号473918-48-8 2-indol-1-ylaniline | CAS号61797-79-3 N-methyl-N-[2-[...

1,2-Diformyldiaminocyclohexane,氢化铝锂,乙醚 以35%的收率获得产物
参考文献:Betschart,Claudia;Schmidt,Beat;Seebach,Dieter,Helv. Chim. Acta,71,(1988) N,C. 1991-2021
标题:Betschart,Claudia;Schmidt,Beat;Seebach,Dieter,Helv. Chim. Acta,71,(1988) N,C. 1991-2021

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-10472325-B2
优先权日:2015-10-29
标题:Process for the synthesis of pirfenidone
发明人：MOSSOTTI MATTEO; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of Pirfenidone (1) from 5-methyl-2(1H)-pyridinone and chlorobenzene in the presence of a catalytic system consisting of a copper salt and an organic ligand, in the presence of a base. n n n n n n n n n n The process exploits the high efficiency of the catalytic system consisting of copper(I) salt and an organic ligand in the presence of an inorganic base in the N-amidation reaction of chlorobenzene, a cheap reagent also usable as solvent in this case; reaction conditions at high temperatures, at atmosphere pressure or higher, produce a reaction with good yields.

专利号:US-7919627-B2
优先权日:2005-05-02
标题:Processes for the preparation of hydroxylamines
发明人：TANG DATONG; QIU YAO-LING; KIM HEEJIN; OR YAT SUN; WANG ZHE
权利人:ENANTA PHARM INC
摘要:The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):

专利号:US-6066737-A
优先权日:1995-12-28
标题:Process for the preparation of optically enriched 4-aryl-3-hydromethyl substituted piperidines to be used as intermediates in the synthesis of paroxetine
发明人：ADGER BRIAN MICHAEL; POTTER GERARD ANDREW; FOX MARTIN EDWARD
权利人:CHIROTECH TECHNOLOGY LTD
摘要:The subject invention pertains to optically-enriched compounds of formula (1), wherein Ar is a C 6-20 aryl group; and R 1 and R 2 are independently H, alkyl or aryl. The subject invention also pertains to method of preparing these compounds. The subject compounds can be prepared by reduction of the corresponding 1,4-dihydropyridine-3-aldehyde, e.g., using hydrogen an a catalyst. The aldehyde can be prepared by hydrolytic cleavage of an aminal obtainable by the reaction of 3-pyridinecarboxaldehyde and a chiral C-2 symmetric diamine, an then stereoselective introduction of the Ar and COOCHR 1 R 2 groups. ##STR1##

专利号:US-9045462-B2
优先权日:2012-08-17
标 题 :Synthesis of an antiviral compound
发明人：EVANS JARED WAYNE; FUJIMORI SHINJI; HUYNH GRACE M; LIU QI; TERESK MARTIN GERALD
权利人:GILEAD SCIENCES INC
摘要:The present disclosure provides processes for the preparation of a compound of Formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula.

专利号:US-9265773-B2
优先权日:2011-09-08
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI; MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.