2-乙酰苯甲酸置于potassium Tert-Butylate,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 16.08H,反应生成 1,3-茚满二酮 参考文献:Rapid Synthesis Of Isoquinolinones By Intramolecular Coupling Of Amides And Ketones 标题:Rapid Synthesis Of Isoquinolinones By Intramolecular Coupling Of Amides And Ketones 摘要:通过在存在kot-Bu/dmf的情况下,酰胺和酮的分子内偶联反应,制备了非常好产率的异喹啉酮. DOI:10.1039/c4Ob01948B
专利号:US-6159673-A 优先权日:1996-07-17 标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound 发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI 权利人:FUJI PHOTO FILM CO LTD 摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.
专利号:EP-1473330-B1 优先权日:1996-07-17 标题:Process for the synthesis of oxonol compound 发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI 权利人:FUJI PHOTO FILM CO LTD 摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.
专利号:WO-2024260915-A1 优先权日:2023-06-19 标题:Dynamic covalent chemistry of spiropyrans for synthesis of photoswitchable photoinitiators and uses thereof 发明人:GARMSHAUSEN YVES 权利人:XOLO GMBH 摘要:The present invention relates to spiropyrans and process for the manufacture of them. In particular, a method is provided to exchange the indole and salicylaldehyde part of a spiropyran in a reversible reaction. The method is used for the synthesis of dual color photoinitiators with specific substituents and substitution patterns, which result in improved dual color volumetric printing (xolography). Furthermore, a process for locally polymerizing a starting material by dual color photopolymerization is disclosed.
专利号:WO-9915510-A1 优先权日:1997-09-24 标 题:Protecting and linking groups for organic synthesis 发明人:TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY 权利人:ALCHEMIA PTY LTD; TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY 摘要:This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups which are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis. In its most general aspect, the invention provides a cyclic compound of general formula (I).
专利号:US-6765089-B1 优先权日:1997-09-24 标 题 :Protecting and linking groups for organic synthesis on solid supports 发明人:TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY 权利人:ALCHEMIA PTY LTD 摘要:This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups that are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis.
专利号:US-2003050305-A1 优先权日:2000-05-22 标题:Thromboxane inhibitors, compositions and methods of use 发明人:TEJADA INIGO SAENZ DE 摘要:The present invention describes methods for treating or preventing sexual dysfunctions in males and females, and for enhancing sexual responses in males and females by administering a therapeutically effective amount of at least one thromboxane inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The male or female may preferably be diabetic. The present invention also provides novel compositions comprising at least one thromboxane inhibitor, and, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and, optionally, at least one therapeutic agent, such as, vasoactive agents, nonsteroidal antiinflanmmatory compounds (NSAIDs), selective cyclooxygenase-2 (COX-2) inhibitors, anticoagulants, angiotensin converting enzymes (ACE) inhibitors, angiotensin II receptor antagonists, renin inhibitors, and mixtures thereof. The present invention also provides methods for treating or preventing ischemic heart disorders, myocardial infarction, angina pectoris, stroke, migraine, cerebral hemorrhage, cardiac fatalities, transient ischaemic attacks, complications following organ transplants, coronary artery bypasses, angioplasty, endarterectomy, atherosclerosis, pulmonary embolism, bronchial asthma, bronchitis, pneumonia, circulatory shock of various organs, nephritis, graft rejection, cancerous metastases, pregnancy-induced hypertension, preeclampsia, eclampsia, thrombotic and thromboembolic disorders, intrauterine growth, gastrointestinal disorders, renal diseases and disorders, disorders resulting from elevated uric acid levels and dysmenorrhea, and for inhibiting platelet aggregation or platelet adhesion or relaxing smooth muscles.
[参考文献]: A Schulman, Et Al. Diphacinone-Induced Coagulopathy In The Dog. J Am Vet Med Assoc. 1986 Feb 15;188(4):402-5. [参考文献]: C Y Wang, Et Al. Inhibition By Diacylmethane Derivatives Of Mutagenicity And Nucleic Acid Binding Of 2-Aminofluorene Derivatives. J Natl Cancer Inst. 1989 Nov 15;81(22):1743-7. [参考文献]: C Y Wang, Et Al. Inhibition By Diacylmethane Derivatives Of Mutagenicity In Salmonella Typhimurium And Trna-Binding Of Chemical Carcinogens. Mutat Res. 1991 Mar;262(3):189-93. [参考文献]: E Marchut, Et Al. [参考文献]: Folia Med Cracov. 1980;22(3-4):331-9. [参考文献]: H C Li, Et Al. The Mobility Of Troponin C And Troponin I In Muscle. J Mol Recognit. 1997 Jul-Aug;10(4):194-201.
合成参考文献
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2018) 3, 166. 摘要:Ayad, T.; Pirat, J.-L.; Virieux, D., Science of Synthesis Knowledge Updates, (2022) 1, 293. 摘要:Shaabani, A.; Sarvary, A.; Shaabani, S., Science of Synthesis: Multicomponent Reactions, (2013) 2, 103. 摘要:Elliott, M. C.; Jones, D. H., Science of Synthesis: Multicomponent Reactions, (2013) 2, 280. 摘要:Rodriguez, J.; Bonne, D.; Coquerel, Y.; Constantieux, T., Science of Synthesis: Multicomponent Reactions, (2013) 2, 1.