CAS: 59025-55-7; 2,4-Difluorophenylisocyanate

上下游产品

CAS号75-44-5 光气 | CAS号367-25-9 2,4-二氟苯胺 | CAS号130804-35-2 来西贝特 | CAS号839713-36-9 Nelotanserin

2,4-二氟苯胺置于硫酸体系中,用 甲苯 作为反应溶剂,化学反应 2.0H,反应生成 2,4-二氟苯基异氰酸酯
参考文献:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series
标题:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series
摘要:A Convenient Synthesis Of Known And Unknown Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series,Involving Silylation Of Starting Amines With Hexamethyldisilazane Or Chlorotrimethylsilane,Followed By Phosgenation Of The Resulting N-Silyl-Substituted Amines. An Unusual High-Temperature Rearrangement Of 3-(Methoxycarbonyl)-4,5-Dimethylthiophene-2-Yl Isocyanate Into Its 5-Ethyl Isomer. Ortho-Fluorine Substituent In Anilines Decreases The Yield Of Isocyanates,Whereas 2,3,5,6-Tetrafluorophenyl Isocyanate Exists For Only A Short Time As A 5% Toluene Solution.
DOI:10.1134/s1070363206010208

专利信息

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:RU-1838301-C
优先权日:1988-07-12
标 题 :Method of synthesis of quinoline derivative or its salt

专利号:US-2004106598-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting Beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2005192269-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2005267150-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds