专利号:US-11274081-B2 优先权日:2016-05-30 标 题:Process for the synthesis of ivacaftor 发明人:REDDY DUMBALA SRINIVASA; KULKARNI AMOL ARVIND; NATARAJAN VASUDEVAN; SHARMA MRITYUNJAY KESHAVPRASAD 权利人:COUNCIL SCIENT IND RES 摘要:The present disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The present invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.
专利号:US-9006150-B2 优先权日:2004-11-08 标题:Structural nucleic acid guided chemical synthesis 发明人:HANSEN NILS JOKOB VEST; BLAKSKJAER PETER; HANSEN MARGIT HAAHR; PETERSEN LARS KOLSTER; HEITNER TARA RENEE 权利人:HANSEN NILS JOKOB VEST; BLAKSKJAER PETER; HANSEN MARGIT HAAHR; PETERSEN LARS KOLSTER; HEITNER TARA RENEE; VIPERGEN APS 摘要:Disclosed is a composition comprising the nucleic acid and a chemical compound, said composition forming a star structure defining 3 or more stems extending from a reaction center. The stems are formed by a nucleic acid duplex and the chemical compound has been formed in the reaction center as the reaction product of 3 or more chemical groups. The advantage of the composition is that a close proximity is provided between the chemical groups in the reaction center, thereby promoting a reaction. The invention also relates to a method for preparation of the composition. The advantage of the method is that it does not require the pre-synthesis of a large number of templates and that it is not dependent upon codon/anti-codon recognition for an encoded molecule to be formed.
专利号:US-8987451-B2 优先权日:2012-01-03 标题 :Synthesis of cyclometallated platinum(II) complexes 发明人:TSAI JUI-YI; KOTTAS GREGG; YEAGER WALTER 权利人:UNIVERSAL DISPLAY CORP 摘要:A single-step method of making tetradentate platinum complexes is disclosed. The method advantageously allows the formation of a platinum complex in a single step, even with sterically hindered ligands, without the use of highly reactive intermediates. The compounds made by the disclosed method are useful in OLED applications.
专利号:WO-2004009574-A1 优先权日:2002-07-22 标 题 :Synthesis of discodermolide 发明人:FLORENCE GORDON; KOCH GUIDO; LOISELEUR OLIVIER; MICKEL STUART JOHN; PATERSON IAN 权利人:NOVARTIS AG; NOVARTIS PHARMA GMBH; UNIV CAMBRIDGE TECH; FLORENCE GORDON; KOCH GUIDO; LOISELEUR OLIVIER; MICKEL STUART JOHN; PATERSON IAN 摘要:The invention relates to a process for preparing discodermolide, for preparing intermediates for the manufacture of discodermolide and discodermolide analogues and to the intermediates obtained during the process. Wherein the process proceeds via a tetraene of formula (IV).
专利号:CA-2428283-C 优先权日:2000-11-13 标题 :Processes for continuous synthesis of polymer compositions as well as use of same
专利号:US-2013172561-A1 优先权日:2012-01-03 标 题:Synthesis of cyclometallated platinum(ii) complexes
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