CAS: 459-59-6; 4-Fluoro-N-Methylaniline

上下游产品

4-fluoro-N,N-dimethylaniline N-(4-fluoro-phenyl)-N-methyl-acetamide N-(4-fluorophenyl)formamide 1,3,5-tris(4-fluorophenyl)-1,3,5-triazinane N-methyl-N-(4-fluorophenyl)carbamoyl chloride N-(4-Fluoro-phenyl)-N-methyl-S-trimethylsilanylethynyl-thiohydroxylamine methyl>-2,4-quinazolinediyl>bisbenzamideN,N'-6-(4-fluorophenyl)methylaminomethyl-2,4-quinazolinediylbisbenzamide -2-propanone3-(4-fluorophenyl)methylamino-2-propanone

1,3,5-三(4-氟苯基)-1,3,5-三嗪置于sodium Hydroxide,Dimethyl Sulfide Borane,碘体系中,化学反应生成 4-氟-N-甲基苯胺
参考文献:苯胺单甲基化的简便方法1
标题:苯胺单甲基化的简便方法1
摘要:摘要 1,3,5-三苯基六氢-1,3,5-三嗪与bh3.s(Ch3)2反应,然后水解,以高收率实现了苯胺的单甲基化.
DOI:10.1080/00397919708006091

专利信息

专利号:US-9518014-B2
优先权日:2012-07-20
标 题:Process for synthesis of ezetimibe and intermediates used in said process
发明人：DING KUILING; WANG XIAOMING; WANG ZHENG
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of β-arylamino α-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of β-arylamino α-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:WO-2024163852-A1
优先权日:2023-02-03
标题:Histidine kinase inhibitors as antibacterial agents
发明人：CARLSON ERIN ELIZABETH; GOSWAMI MANIBARSHA; ESPINASSE ADELINE; JI YINDUO
权利人:UNIV MINNESOTA
摘要:The invention provides maleimide derivative compounds of Formula I, as histidine kinase inhibitors, useful for inhibiting bacterial histidine kinases, such as HK853 and AirS, for treating S. aureus bacterial infections, in particular methicillin-resistant S. aureus (MRSA). The invention further provides methods of treating bacterial infection with the. compounds of Formula I, either used alone or in combination with other agents in a therapeutic regimen. Further disclosed is the synthesis of the compounds of Formula I.

专利号:US-2015166479-A1
优先权日:2012-07-20
标 题 :Process for synthesis of ezetimibe and intermediates used in said process

专利号:CN-109678806-A
优先权日:2018-12-24
标题 :A kind of efficient monomethylation synthesis method of aromatic primary amine

专利号:US-6207836-B1
优先权日:1993-02-17
标 题 :Indolin-2-one derivatives
发明人：ESAKI TORU; EMURA TAKASHI; HOSHINO EIICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:A compound represented by formula (I):wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, -OR5, -SR5 or -NR6R7 (wherein R5, R6, and R7 each represent a lower alkyl group, etc.); X and Y each represent -CH2-, -NH- or -O-; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed. The compound of the present invention exhibits selective antagonism against gastrin receptors without causing side effects attributed to CCK-A receptor antagonism and is useful for the treatment and prevention of peptic ulcers, gastritis, reflux esophagitis, and Zollinger-Ellison syndrome, and for the treatment of neoplasm originating in the gastrointestinal system.