CAS: 42019-78-3; (4-Chlorophenyl)(4-Hydroxyphenyl)Methanone

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CAS号122-01-0 4-氯苯甲酰氯 | CAS号108-95-2 苯酚 | CAS号622-32-2 苯甲醛肟 | CAS号7497-60-1 (4-氯苯基)(4-硝基苯基)甲酮 | CAS号2069-48-9 (4-氯苯基)(4-氟苯基)甲酮 | CAS号100-66-3 苯甲醚 | CAS号1871-38-1 4-氯苯甲酸苯酯 | CAS号10547-60-1 4-(4-氯苯甲酰基)苯甲醚 | CAS号462-06-6 氟苯 | CAS号4913-77-3 4-氨基-4-氯苯甲酮 | CAS号49562-28-9 非诺贝特 | CAS号42017-89-0 非诺贝特酸 | CAS号856676-23-8 非诺贝特酸胆碱盐 | CAS号61001-99-8 propan-2-yl 2-[... | CAS号160412-57-7 [4-(2-bromoetho... | CAS号10547-60-1 4-(4-氯苯甲酰基)苯甲醚 | CAS号334931-09-8 4-氯-[4-(1,1,2,2... | CAS号42018-56-4 2-[4-(4-chlorob... | CAS号42017-94-7 2-[4-(4-chlorob... | CAS号52890-73-0 4-[(4-chlorophe...

4-(叔丁基二甲基硅氧基)苯基硼酸置于c42H36Clfen2O4Ppds*c6H15N,四丁基氟化铵,Sodium Carbonate体系中,用 四氢呋喃,水,甲苯 作为反应溶剂,化学反应 1.5H,反应生成 4-氯-4'-羟基二苯甲酮
参考文献:极性膦基二茂铁酰胺基磺酸盐配体的合成及其在水介质中钯催化的芳香族硼酸与酰氯交叉偶联反应中的应用
标题:极性膦基二茂铁酰胺基磺酸盐配体的合成及其在水介质中钯催化的芳香族硼酸与酰氯交叉偶联反应中的应用
摘要:The Reaction Of [1'-(Diphenylphosphino)Ferrocenyl]Methylamine (1),Generated In Situ From Its Hydrochloride And Triethylamine,With 2-Sulfobenzoic Anhydride Afforded An Anionic Phosphino-Amide,Which Was Isolated As A Triethylammonium Salt,Ph(2)Pfcch(2)Nhcoc(6)H(4)So(3)-(Hnet3) (2; Fc = Ferrocene-1,1'-Diyl). A Similar Reaction Of 1 With Phthalic Anhydride Only Furnished The Salt (Ph(2)Pfcch(2)Nh(3))[c6H4Co2H(Co2)]. When It Was Reacted With [pdcl2(Mecn)(2)] And [(Lpd)-Pd-Nc(Mu-Cl)](2) (L-Nc = 2-[(Dimethylamino-Kappa N)Methyl]Phenyl-Kappa C-1),Compound 2 Gave Rise To The Bisphosphine Complex [pdcl2(2-Kappa P)(2)] And The Bridge-Cleavage Product [(Lpdcl)-Pd-Nc(2-Kappa P)],Respectively. An Analogue Of The Latter Complex Containing 2'-Amino-[1,1'-Biphenyl]-2-Yl-Kappa N-2,C-2 As The Auxiliary Chelating Ligand,Compound 8,Was Prepared In A Similar Manner From 2 And The Respective Pd Precursor. Finally,The Reaction Of 2 With [(Lpd)-Pd-Nc(Acac)] Proceeded With The Replacement Of The Acetylacetonate Ligand (Acac),Affording A Dipalladium Complex Featuring Two Phosphinosulfonate Anions As The O,P-Bridges,[(Lpd)-Pd-Nc(Mu(P,O)-Ph(2)Pfcch(2)Nhcoc(6)H(4)So(3))](2),Which Was Structurally Characterized By Single-Crystal X-Ray Diffraction Analysis. All Of These Pd(II) Complexes,Especially Compound 8,Formed Active Catalysts For Pd-Mediated Cross-Coupling Of Aromatic Boronic Acids With Benzoyl Chlorides To Produce Substituted Benzophenones In Toluene (Benzene) Water Biphasic Mixtures. This Particular Coupling Reaction Was Employed During The Preparation Of 4'-Chloro-4-Hydroxybenzophenone,Which Was In Turn Converted To Fenofibrate,A Generic Drug Widely Used To Reduce Cholesterol Levels In Blood.
DOI:10.1021/acs.Organomet.6B00600

专利信息

专利号:US-8445715-B2
优先权日:2007-07-02
标 题 :Method of synthesizing fenofibrate
发明人：LUCAS BEATRICE
权利人:LUCAS BEATRICE; SYNKEM
摘要:A novel process for the synthesis of fenofibrate, includes reacting a metal salt of fenofibric acid with an isopropyl halide, in a solvent system composed of a mixture of dimethyl sulfoxide and a C 2 -C 4 alkyl acetate. The process can be used on an industrial scale and makes it possible to obtain a fenofibrate of a quality in accordance with the Pharmacopoeia without the need for purification by recrystallization.

专利号:EP-0377198-A2
优先权日:1988-12-31
标题:Chloroformiates of aromatic ketones, and process for their preparation
发明人：BOETTCHER ANDREAS DR; HENKELMANN JOCHEM DR
权利人:BASF AG
摘要:The invention relates to chloroformates of aromatic ketones and their preparation from aromatic hydroxyketones by phosgenation in the presence of acidic catalysts.n n n The chloroformates according to the invention are intermediates for the synthesis of organic compounds.

专利号:US-8008406-B2
优先权日:2007-05-23
标题:Synthesis and characterization of a novel proton exchange membrane (PEM) for applications in fuel cells
发明人：SALANITRI MARCO ANTONIO; CONSIGLIO GIUSEPPE; LEO CHIARA SILVANA; CALAMIA STEFANIA
权利人:ST MICROELECTRONICS SRL
摘要:A fuel cell membrane is described comprising at least one sulfonated aromatic polyether copolymer comprising a poly-arylen-ether-ketone (PEK) moiety or sulfonated derivatives thereof, deriving from spiro-bis-indane or 4,4′-(hexafluoroisopropylidene)diphenol (BPAF), and an arylene-sulfone, or an arylene-ketone or sulfonated derivative thereof; said copolymer having the following formula (1): n nwherein Ar 1 has formula,n n nwherein X is spiro-bis-indanile (SBI) (b) or BPAF (c) having formulas:n n nand wherein Y is H or SO 3 H, andn nAr 2 has formulan n nwherein W is CO or SO 2 , and Y is H or SO 3 H, wherein Z is OH or Cl; and wherein at least one between Ar 1 or Ar 2 comprise at least one sulfonic group; and wherein n is an integer comprised between 2 and 50. A method for the production of such membrane is also described.

专利号:US-7858825-B2
优先权日:2007-02-15
标题:Acid and base stable diphenylmethanol derivatives and methods of use
发明人：KUROSU MICHIO; CRICK DEAN
权利人:UNIV COLORADO STATE RES FOUND
摘要:The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same.

专利号:RU-2373230-C2
优先权日:2006-05-13
标题 :Method of processing reaction mixture formed during nucleophilic synthesis of polyarylene ether ketones

专利号:JP-2010531852-A
优先权日:2007-07-02
标题 :A new synthesis of fenofibrate