CAS: 404-24-0; 2,2,2-Trifluoro-N-Phenylacetamide

上下游产品

diethyl ether trifluoroacetic anhydride aniline benzoic trifluoroacetic anhydride 2,2,2-Trifluoro-N-methyl-N-phenyl-acetamide 2,2,2-trifluoro-N-phenylethanethioamide N-benzyl-2,2,2-trifluoro-N-phenylacetamide

📜2,2,2-Trifluoro-N-Phenylethanethioamide置于1,2,3,4,5,6,7,8-八硫杂环辛烷,Potassium Phosphate,1,10-菲罗啉,水,Magnesium Sulfate,Copper(L) Chloride体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 4.0H,以35%的收率获得产物三氟乙酰苯胺
参考文献:Copper-Catalyzed Three Component C S/c N Coupling For The Synthesis Of Trifluorothioacetamides
标题:Copper-Catalyzed Three Component C S/c N Coupling For The Synthesis Of Trifluorothioacetamides
摘要:A Copper-Catalyzed Three Component C-S/c-N Coupling Reaction Of Imines With Sulfur And Cfc-113A Was Developed. The Reaction Involves Amination And C = S Double Bond Formation Of Cfc-113A,Leading To Biologically Important Trifluorothioacetamides. The Method Features Efficient Construction Of Trifluorothioacetyl Moiety From Cheap Sulfur And Cfc-113A,And Safe Disposal For Environmentally Persistent Freon.
DOI:10.1016/j.Jfluchem.2020.109640

专利信息

专利号:US-8901352-B2
优先权日:2011-01-13
标题 :Method for the synthesis of rasagiline
发明人：REIS ÖMER; KOYUNCU HASAN; ESIRINGU ILKER; SAHIN YASEMIN; GULCAN H OZAN
权利人:REIS ÖMER; KOYUNCU HASAN; ESIRINGU ILKER; SAHIN YASEMIN; GULCAN H OZAN; NOBEL ILAÇ SANAYII VE TICARET A S
摘要:We have developed a new method for the synthesis of Rasagiline (Formula 1) based on the alkylation of trifluoroacetyl protected aminoindan. This protection enabled us to carry out an alkylation of aminoindan with a high yield and purity under very mild conditions with a wide range of reaction conditions and reagent selection. Considering the ease, purity and high yields of introducing and removal of the trifluoroacetyl group, this approach is a highly practical and economical way for the synthesis of rasagiline or its pharmaceutically acceptable salts.

专利号:US-2024024489-A1
优先权日:2020-11-20
标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof
发明人：MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE
权利人:PASTEUR INSTITUT
摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)

专利号:US-9938312-B2
优先权日:2011-03-25
标题 :Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans
发明人：BOONS GEERT-JAN; WANG ZHEN
权利人:BOONS GEERT JAN; WANG ZHEN; UNIV GEORGIA
摘要:The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.

专利号:US-11834468-B2
优先权日:2017-07-03
标 题:Protected tetrasaccharides, their process of preparation and their use as transglucosylase acceptor substrates in the chemo-enzymatic synthesis of Shigella flexneri specific oligosaccharides
发明人：MULARD LAURENCE; LE HEIGET GUILLAUME; HU ZHAOHU; BAREL LOUIS-ANTOINE; ANDRE ISABELLE; MOULIS CLAIRE; REMAUD-SIMEON MAGALI; BARBE SOPHIE; BENKOULOUCHE MOUNIR; BEN IMEDDOURENE AKLI
权利人:PASTEUR INSTITUT; AGRONOMIQUE INST NAT RECH; INSTITUT NAT DES SCIENCES APPLIQUEES DE TOULOUSE; CENTRE NAT RECH SCIENT
摘要:The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.

专利号:US-2014234364-A1
优先权日:2011-09-23
标 题:Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis
发明人：SEEBERGER PETER H; YANG YOU; ANISH CHAKKUMKAL; REINHARDT ANIKA
权利人:MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V
摘要:The present invention relates to the total chemical synthesis of the monosaccharide 35 # (R′â•?H), the disaccharide 36 # (R′≠H; R″â•?H), the trisaccharide 37 # (R′≠H; R″≠H; R′″≠H) and the tetrasaccharide 1 # (R′≠H; R″≠H; R′″≠H) of the following general formula wherein R represents —Y—NH 2 Y represents a linker R′ is H or R″ is H or R′″ is H or of the lipopolysaccharide from Neisseria meningitidis , as well as to the trisaccharide 37 # and the tetrasaccharide 1 # , to vaccines containing at least one of the saccharides 1 # , 35 # , 36 # , and 37 # and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide α-GlcNAc-(1→2)-α-Hep-( 1→3 )-α-Hep-(1→5)-α-Kdo or the trisaccharide α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo or α-GlcNAc-(1→2)-±-Hep-(1→3)-α-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.

专利号:US-8420607-B2
优先权日:2006-06-30
标 题 :Anthrax carbohydrates, synthesis and uses thereof
发明人：CARLSON RUSSELL W; BOONS GEERT-JAN; QUINN CONRAD; VASAN MAHALAKSHMI; WOLFERT MARGREET A; BUSKAS THERESE; CHOUDHURY BISWA; KANNENBERG ELMAR; LEOFF CHRISTINE; MEHTA ALOK; SAILE ELKE; RAUVOLFOVA JANA; WILKINS PATRICIA
权利人:CARLSON RUSSELL W; BOONS GEERT-JAN; QUINN CONRAD; VASAN MAHALAKSHMI; WOLFERT MARGREET A; CHOUDHURY BISWA; KANNENBERG ELMAR; LEOFF CHRISTINE; MEHTA ALOK; SAILE ELKE; RAUVOLFOVA JANA; WILKINS PATRICIA; HARVEY ALEX J; UNIV GEORGIA; US HEALTH
摘要:The present invention presents the isolation, characterization and synthesis of oligosaccharides of Bacillus anthracis . Also presented are antibodies that bind to such saccharide moieties and various methods of use for such saccharide moieties and antibodies.