📜2-硝基-Alpha,Alpha,Alpha-三氟甲苯置于镍 氢气体系中,用 Petroleum Ether 用作溶剂,化学反应生成2-(三氟甲基)苯基肼 参考文献:The Synthesis Of 1-,2-And 3-Trifluoromethylcarbazoles By The Fischer-Indole Method 标题:The Synthesis Of 1-,2-And 3-Trifluoromethylcarbazoles By The Fischer-Indole Method 摘要: Doi:10.1016/s0040-4020(01)93332-0
专利号:US-6960601-B2 优先权日:2001-09-24 标题 :Preparation and use of imidazole derivatives for treatment of obesity 发明人:SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG 权利人:BAYER PHARMACEUTICALS CORP 摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
专利号:CN-115124430-A 优先权日:2022-07-11 标 题 :A kind of synthesis technique of 2,2'-bis(trifluoromethyl)diaminobiphenyl
专利号:US-8030311-B2 优先权日:2005-04-14 标题:Phenylacetamides suitable as protein kinase inhibitors 发明人:BOLD GUIDO; FURET PASCAL; GUAGNANO VITO; MCCARTHY CLIVE; VAUPEL ANDREA 权利人:NOVARTIS AG 摘要:The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.
专利号:CN-107663161-A 优先权日:2016-07-27 标 题 :A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt
专利号:CN-115124430-B 优先权日:2022-07-11 标题:A synthesis process of 2,2'-bis(trifluoromethyl)diaminobiphenyl
[参考文献]: W T Ashton, Et Al. Nonpeptide Angiotensin Ii Antagonists Derived From 1H-Pyrazole-5-Carboxylates And 4-Aryl-1H-Imidazole-5-Carboxylates. J Med Chem. 1993 Nov 12;36(23):3595-605.
合成参考文献
摘要:Begtrup, M.; Rasmussen, L. K., Science of Synthesis, (2007) 31, 1781. 摘要:Rück-Braun, K.; Dietrich, S.; Kempa, S.; Priewisch, B., Science of Synthesis, (2007) 31, 1468.