CAS: 365-34-4; 2-(Trifluoromethyl)Phenylhydrazine

该化合物是一种专门的九子衍生物,其成分是附于苯环的三氟甲基组,该化合物在有机合成中广泛用作多种用途的中间体,特别是在制作三环化合物,药品和农用化学品时;使用电子提取的三氟乙烷组的存在增强了其反应性,使其对构建复杂的分子框架具有价值;在标准条件下保持稳定,并符合各种反应条件,进一步有助于其在研究和工业应用中的效用;该化合物通常因其氢氮的功能而得到谨慎处理,要求在储存和使用期间采取适当的安全措施.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-(trifluoromethyl)benzenamine o-trifluoromethylbenzene diazonium chloride 2-nitrobenzotrifluoride N-acetyl-3-trifluoromethylbenzenamine 9H10F3N3°C9H10F3N3O 3-[(2-Trifluoromethyl-phenyl)-hydrazono]-piperidin-2-one 5-n-butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (E)-ethyl pyruvate 2-(2-trifluoromethylphenyl)hydrazone

合成工艺路线路线简述

    📜2-硝基-Alpha,Alpha,Alpha-三氟甲苯置于镍 氢气体系中,用 Petroleum Ether 用作溶剂,化学反应生成2-(三氟甲基)苯基肼
    参考文献:The Synthesis Of 1-,2-And 3-Trifluoromethylcarbazoles By The Fischer-Indole Method
    标题:The Synthesis Of 1-,2-And 3-Trifluoromethylcarbazoles By The Fischer-Indole Method
    摘要:
    Doi:10.1016/s0040-4020(01)93332-0

    海关参考信息

    专利信息


    专利号:US-6960601-B2
    优先权日:2001-09-24
    标题 :Preparation and use of imidazole derivatives for treatment of obesity
    发明人:SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
    权利人:BAYER PHARMACEUTICALS CORP
    摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

    专利号:CN-115124430-A
    优先权日:2022-07-11
    标 题 :A kind of synthesis technique of 2,2'-bis(trifluoromethyl)diaminobiphenyl

    专利号:US-8030311-B2
    优先权日:2005-04-14
    标题:Phenylacetamides suitable as protein kinase inhibitors
    发明人:BOLD GUIDO; FURET PASCAL; GUAGNANO VITO; MCCARTHY CLIVE; VAUPEL ANDREA
    权利人:NOVARTIS AG
    摘要:The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

    专利号:CN-107663161-A
    优先权日:2016-07-27
    标 题 :A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt

    专利号:CN-115124430-B
    优先权日:2022-07-11
    标题:A synthesis process of 2,2'-bis(trifluoromethyl)diaminobiphenyl

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: W T Ashton, Et Al. Nonpeptide Angiotensin Ii Antagonists Derived From 1H-Pyrazole-5-Carboxylates And 4-Aryl-1H-Imidazole-5-Carboxylates. J Med Chem. 1993 Nov 12;36(23):3595-605.

    合成参考文献


    摘要:Begtrup, M.; Rasmussen, L. K., Science of Synthesis, (2007) 31, 1781.
    摘要:Rück-Braun, K.; Dietrich, S.; Kempa, S.; Priewisch, B., Science of Synthesis, (2007) 31, 1468.
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