CAS: 258278-25-0; 1,3-Bis(2,6-Diisopropylphenyl)-4,5-Dihydro-1H-Imidazol-3-Ium Chloride

N,N'-双(2,6-二异丙基苯基)乙烷二亚胺置于sodium Tetrahydroborate,Ammonium Tetrafluoroborate,水,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,水 用作溶剂,化学反应 40.0H,反应生成1,3-双-(2,6-二异丙基苯基)咪唑鎓氯化物
参考文献:Pkas Of The Conjugate Acids Of N-Heterocyclic Carbenes In Water
标题:Pkas Of The Conjugate Acids Of N-Heterocyclic Carbenes In Water
摘要:一系列nhcs在水中的共轭酸的pka值报道为19.8至28.2.讨论了环大小,N取代基和c(4)-c(5)饱和度对pka值的影响.
Doi:10.1039/c0Cc03367G

专利信息

专利号:US-11779912-B2
优先权日:2016-10-19
标题 :Synthesis and characterization of Ru alkylidene complexes
发明人：JOHNS ADAM M; HERRON JESSICA R; PEDERSON RICHARD L; FIAMENGO BRYAN A; BEERMAN JENNIFER A; LIN TZU-PIN; CHU CRYSTAL K; GRUBBS ROBERT H
权利人:UMICORE AG & CO KG; CALIFORNIA INST OF TECHN
摘要:This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.

专利号:US-10053426-B2
优先权日:2014-12-23
标 题 :Process for the synthesis of metyrapone and alkylated metyrapone analogs
发明人：WILLIAMS ERIC L; SUNDERHAUS JAMES D; SPRINGER JAMES J
权利人:ALBEMARLE CORP
摘要:Process for preparing metyrapone type compounds are generally described herein. In particular, one step process for preparing metyrapone type compounds are described herein. Such processes generally include an alpha-carbon arylation coupling reaction between 3-isobutyrylpyridine and 3-halopyridine compounds in the presence of a palladium catalyst and a phosphine ligand to form the metyrapone-type compounds.

专利号:US-2022056025-A1
优先权日:2018-09-25
标 题:Synthesis of pyrido[2,3-d]pyrimidin-7(8h)-ones
发明人：BROWN ADAM ROSS; DESROSIERS JEAN-NICOLAS; DUAN SHENGQUAN; HAWKINS JOEL MICHAEL; HAYWARD CHERYL MYERS; MALONEY MARK THOMAS; MONFETTE SEBASTIEN; PERFECT HAHDI HAKIMIOUN; WIDLICKA DANIEL WILLIAM
权利人:PFIZER
摘要:This invention relates to novel methods to prepare substituted pyrido[2,3-d]pyrimidin-7(8H)-ones, and salts and stereoisomers thereof, as well as intermediates useful for the preparation of such compounds.

专利号:US-2013131343-A1
优先权日:2009-12-07
标 题:Microwave-assisted synthesis of n-heterocyclic carbene transition metal complexes
发明人：NAVARRO OSCAR; WINKELMANN OLE H
权利人:NAVARRO OSCAR; WINKELMANN OLE H; UNIV HAWAII
摘要:Microwave heating is used to synthesize NHC-transition metal complexes. Reaction times for the formation of NHC-transition metal complexes is greatly reduced. The speed of the reactions allows for otherwise problematic air handling of reagents. Apparatus for carrying out the reactions is less complex than conventional apparatus and requires less energy to achieve the desired temperatures. Methods utilize salts of NHC's which overcomes the oftentimes difficult preparation of free carbenes for formation of the corresponding transition metal complexes.

专利号:US-2017240485-A1
优先权日:2014-10-21
标 题:Synthesis of Esters by Functionalisation of CO2

专利号:US-12202782-B2
优先权日:2020-11-19
标 题:Processes and intermediates for preparing MCL1 inhibitors
发明人：DIXON DARRYL D; ISCHAY MICHAEL A; JOHNSON TREVOR C; MERIT JEFFREY E; REGENS CHRISTOPHER S; STANDLEY ERIC A; STEINHUEBEL DIETRICH P
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.