CAS: 2505-31-9; 2,4,6-Trichlorophenylisocyanate

上下游产品

CAS号75-44-5 光气 | CAS号632-22-4 四甲基脲 | CAS号634-93-5 2,4,6-三氯苯胺 | CAS号201230-82-2 carbon monoxide | CAS号18708-70-8 2,4,6-三氯硝基苯 | CAS号32315-10-9 三光气 | CAS号7782-50-5 氯气 | CAS号103-71-9 异氰酸苯酯 | CAS号102-07-8 |N|,|N|'-二苯基脲 | CAS号634-93-5 2,4,6-三氯苯胺 | CAS号20632-35-3 N,N-双(2,4,6-三氯苯基)脲 | CAS号97627-27-5 Rho激酶抑制剂II

📜三光气,2,4,6-三氯苯胺置于三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,反应生成异氰酸-2,4,6-三氯苯酯
参考文献:N-Substituted 2-Isonicotinoylhydrazinecarboxamides-New Antimycobacterial Active Molecules
标题:N-Substituted 2-Isonicotinoylhydrazinecarboxamides-New Antimycobacterial Active Molecules
摘要:本报告介绍了一种新的异烟肼(inh)结构修饰,通过两种合成方法获得的羰基与不同的苯胺连接,并制备了通过它们的环化合成的n-取代的5-(吡啶-4-基)-1,3,4-噁二唑-2-胺.所有合成的衍生物均通过ir,NMR,Ms和元素分析进行了表征,并在体外评估了它们对结核分枝杆菌h37Rv,鸟分枝杆菌330/88,堪萨斯分枝杆菌235/80和一种临床分离的堪萨斯分枝杆菌6509/96的抗分枝杆菌活性.2-异烟酰基-N-(4-辛基苯基)酰肼羰酰胺在体外对结核分枝杆菌的疗效与inh相当,最低抑制浓度(mics)为1-2 μm.在卤代衍生物中,2-异烟酰基-N-(2,4,6-三氯苯基)酰肼羰酰胺显示出最佳的抗结核活性(mic = 4 μm).对烯酰基酰基载体蛋白还原酶inha的计算机模拟证实,较长的烷基取代基有利于与inha的相互作用和亲和力.大多数酰肼羰酰胺,特别是那些源自4-烷基苯胺的衍生物,对耐inh的非结核分枝杆菌显示出显著的活性.
Doi:10.3390/molecules19043851

专利信息

专利号:US-4267070-A
优先权日:1979-10-30
标题:Catalyst for the synthesis of aromatic monoisocyanates
发明人：NEFEDOV BORIS K; MANOV-JUVENSKY VLADIMIR I; DERGUNOV JURY I; RYSIKHIN ANATOLY I; CHIMISHKIAN ALEXANDR L
权利人:NEFEDOV BORIS K; MANOV JUVENSKY VLADIMIR I; DERGUNOV JURY I; RYSIKHIN ANATOLY I; CHIMISHKIAN ALEXANDR L
摘要:A catalyst for the synthesis of aromatic monoisocyanates comprising 1.64 to 16.6% by weight of palladium chloride, 0.16 to 47.6% by weight of an oxide of a metal of Group VB of the periodic system, 1.5 to 81.8% by weight of an oxide of a metal of Group VI B of the periodic system, 1.64 to 89.8% by weight of pyridine or an alkylsubstituted pyridine. n The use of the catalyst according to the invention in the synthesis of aromatic monoisocyanates makes it possible to obtain a high degree of conversion of the starting compound of up to 100%, a high yield of the desired product of up to 97%, and increased productivity of the catalyst of up to 40 g of the desired product per g of PdCl 2 per hour.

专利号:US-11655255-B2
优先权日:2022-10-17
标题 :Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
发明人：ZHANG WANBIN; WANG MO; ZHANG LU; HUO XIAOHONG; ZHANG ZHENFENG; YUAN QIANJIA; CHEN JIANZHONG
权利人:SPH NO 1 BIOCHEMICAL & PHARMACEUTICAL CO LTD; UNIV SHANGHAI JIAOTONG
摘要:A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3)

专利号:US-2023085986-A1
优先权日:2022-10-17
标 题:Method for catalytic asymmetric synthesis of phosphorus-stereogenic (p-stereogenic) nucleoside derivative and catalyst used therein

专利号:SU-906601-A1
优先权日:1980-04-25
标题:Catalyst for synthesis of monochloropnemylisocyanates

专利号:US-4477389-A
优先权日:1982-10-25
标 题 :Polyhalogenated phenyl isocyanate synthesis with excess phosgene and either triethylamine or tetramethylurea
发明人：CHEN GEORGE C; ROWELL ROGER M
权利人:US AGRICULTURE
摘要:Two procedures are described that can be used to prepare polyhalogenated phenyl isocyanates (2,4,6-trichloro,2,3,5,6-tetrachloro, pentachloro, 2,4,6-tribromo and 2,4,6-trifluoro derivatives) from the corresponding anilines in good yields (95-99%) with small amounts of urea byproducts (1-5%) within reasonable reaction times (3-6 hours). These are: n 1. Liquid phase phosgenation of polyhalogenated anilines with tertiary amines as a hydrogen chloride acceptor. n 2. Liquid phase phosgenation of polyhalogenated anilines in excess phosgene at the beginning and throughout the reaction.

专利号:CN-113754692-A
优先权日:2020-06-03
标题 :Asymmetric catalytic synthesis method of Ruideciclovir intermediate (S, S) -phosphoramidate