CAS: 2485-71-4; 13-Methyltetradecanoic Acid

上下游产品

diazomethane isomyristic acid methyl 13-methyltetradecanoate (R)-15-Methyl-3-(13-methyl-tetradecanoyloxy)-hexadecanoic acid benzhydryl ester (S)-15-Methyl-3-(13-methyl-tetradecanoyloxy)-hexadecanoic acid benzhydryl ester (S)-2-Amino-hexanedioic acid 6-benzyl ester 1-((S)-1-carbamoylmethyl-13-methyl-tetradecyl) ester

13-甲基十四烷酸甲酯置于sodium Hydroxide体系中,用 乙醇 用作溶剂,化学反应 4.0H,以89%的收率获得13-甲基十四烷酸
参考文献:扩展支链脂肪酸的构效关系:不饱和度和支链基团大小对抗癌活性的影响.
标题:扩展支链脂肪酸的构效关系:不饱和度和支链基团大小对抗癌活性的影响.
摘要:支链脂肪酸(bcfa)是一类具有非常好抗癌活性的脂肪酸.Bcfa 13-甲基十四烷酸(13-Mtd)在体内抑制肿瘤生长而无毒性,但功效受限于中等效力,这是所有已知bcfa共有的特性.Bcfas的作用机理尚未完全阐明,在缺乏明确定义的靶标的情况下,Bcfa效能的优化必须依赖于结构-活性关系.我们目前对促进bcfa抗癌活性的结构特征的理解受到所报道的bcfa的低结构多样性的限制.本研究的目的是研究两种新的结构修饰-不饱和和支链基团大小-对bcfa活性的影响.因此,饱和和顺式的同源序列合成了带有甲基,乙基,丙基和丁基支化基团的-δ11不饱和bcfa,并在体外针对三种人类癌细胞系进行了筛选.将新bcfa的效力与13-Mtd和带有顺式-δ11双键的直链单未饱和脂肪酸(mufa)进行了比较.出现的主要发现是,Bcfa的抗癌活性受到较大分支基团的不利影响,但通过在bcfa烷基链中引入顺式-δ11双键而显着
Doi:10.1016/j.Chemphyslip.2020.104952

专利信息

专利号:US-2008300418-A1
优先权日:2004-11-08
标 题:Synthesis of Cardiolipin Analogues and Uses Thereof
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
权利人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
摘要:The invention provides novel synthetic methodologies for preparing cardiolipin, migrated caridiolipin (1,2-positional isomer of cardiolipin) and their analogues having varying fatty acids and/or alkyl chains with varying length and degrees of saturation/unsaturation. The method comprises (a) reacting an optically pure 1,2-O-dialkyl-sn-glycerol or 1,2-O-dialkyl-sn-glycerol with one or more phosphoramidite reagent(s), wherein a phosphite triester is produced; (b) coupling the product of (a) with glycerol, wherein a protected cardiolipin is produced; and (c) deprotecting the protected cardiolipin, such that cardiolipin is prepared. The cardiolipins and analogues thereof, prepared by the present methods, can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs, antisense nucleotides or diagnostic agents. Such liposomes can be used to treat diseases or can be used in diagnostic and/or analytical assays.

专利号:US-2017246690-A1
优先权日:2014-06-20
标 题:Stabilizing agent-free metal nanoparticle synthesis and uses of metal nanoparticles synthesized therefrom
发明人：MURPHY RYAN J; DREYFUS REMI; HOUGH LAWRENCE ALAN; MALASSIS LUDIVINE; MURRAY CHRISTOPHER; DONNIO BERTRAND
权利人:RHODIA OPERATIONS; CENTRE NAT RECH SCIENT; UNIV PENNSYLVANIA
摘要:Described herein are methods of synthesizing metal nanoparticles and the metal nanoparticles synthesized therefrom. Further described in the present disclosure are methods of modifying the surfaces of metal nanoparticles and the metal nanoparticles modified thereby. Also described herein are uses of such metal nanoparticles.

专利号:US-2008286351-A1
优先权日:2004-06-29
标 题:Pegylated Cardiolipin Analogs, Methods of Synthesis, and Uses Thereof
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
权利人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
摘要:The invention provides synthetic methods for PEGylated cardiolipins with varying linkers. The methods can be employed to prepare PEGylated cardiolipin with different fatty acid and/or alkyl chain length with or without unsaturation. The PEGylated cardiolipin, prepared by the present methods, can be incorporated into liposomes that can also include active agents such as hydrophilic or hydrophobic drugs for the treatment of human and animal diseases. In addition, the PEGylated cardiolipin can be incorporated into liposomes that include compounds for therapeutic and diagnostic imaging. The use of such liposomes with PEGylated cardiolipin prolongs the period of liposomal circulation without disrupting the lipid bilayer.

专利号:US-2005266068-A1
优先权日:2002-05-24
标题 :Cardiolipin molecules and methods of synthesis
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; AHMAD IMRAN
权利人:NEOPHARM INC
摘要:The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation, particularly a short-chain cardiolipin. The methods comprise reacting a 1,2-O-sn-diacyl/1,2-O-sn-dialkyl glycerol or a 2-O-protected glycerol, with a phosphoramidite reagent or a phosphate triester to produce a protected cardiolipin, which is deprotected to prepare the short chain cardiolipin. The reaction schemes can be used to generate new variants of cardiolipin. The cardiolipin prepared by the present methods can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs. Such liposomes can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes can also include ligands for targeting a particular cell type or specific tissue.

专利号:US-6214875-B1
优先权日:1998-04-14
标题:Anticancer effects of specific branched-chain fatty acids and related production process
发明人：YANG ZHENHUA
摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.

专利号:CN-106852132-A
优先权日:2014-06-20
标题:Stabilizer-free synthesis of metal nanoparticles and use of metal nanoparticles synthesized therefrom