CAS: 220000-87-3; 4-Chloro-N-Methylpicolinamide

上下游产品

CAS号284462-78-8 4-(3-氨基苯氧基)-N-甲... | CAS号882167-77-3 4-氯-N-甲基吡啶-2-甲酰胺盐酸盐 | CAS号757251-39-1 4-(4-氨基-3-氟苯氧基)... | CAS号284461-73-0 索拉非尼 | CAS号284462-37-9 4-(4-氨基苯氧基)-N-甲... | CAS号1020172-07-9 N-[3-叔丁基-1-(喹啉-... | CAS号827025-40-1 ethyl 3-[2-(met... | CAS号827025-42-3 ethyl 4-[2-(met... | CAS号827029-02-7 N-methyl-4-(3-n... | CAS号877874-02-7 4-((3-氨基苯并[e][1...

甲胺置于magnesium Chloride体系中,用 四氢呋喃 用作溶剂,化学反应 16.41H,以81%的收率获得n-甲基-4-氯-2-吡啶甲酰胺
参考文献: Heterocyclic Substituted Bisarylurea Derivatives As Kinase Inhibitors[fr] Derives De Bisaryluree Substitues,Heterocycliques,Utilises En Tant Qu'Inhibiteurs De Kinases
标题: Heterocyclic Substituted Bisarylurea Derivatives As Kinase Inhibitors[fr] Derives De Bisaryluree Substitues,Heterocycliques,Utilises En Tant Qu'Inhibiteurs De Kinases
摘要:本发明涉及公式i的杂环取代双芳基脲衍生物,公式i化合物作为一种或多种激酶的抑制剂的用途,公式i化合物用于制备药物组合物以及一种治疗方法,包括向患者施用所述药物组合物.

专利信息

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人：WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

专利号:JP-4403482-B2
优先权日:1997-12-22
标题 :Intermediates for the synthesis of substituted heterocyclic ureas and methods for their preparation

专利号:CN-104910067-A
优先权日:2015-03-05
标 题:Method for one-pot synthesis of regorafenib

专利号:US-9861636-B2
优先权日:2014-04-29
标题 :Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
发明人：HE WEI
权利人:HE WEI; ZHEJIANG DTRM BIOPHARMA CO LTD
摘要:Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.