专利号:US-10005720-B2 优先权日:2013-04-05 标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same 发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L 权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL 摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:US-2018370905-A1 优先权日:2013-04-05 标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same
专利号:US-2016046560-A1 优先权日:2013-04-05 标题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same
专利号:WO-2014165816-A1 优先权日:2013-04-05 标 题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same
专利号:WO-2010001220-A1 优先权日:2008-07-01 标 题 :New 1,2,4-triazine derivatives and biological applications thereof 发明人:DESROY NICOLAS; DENIS ALEXIS; GERUSZ VINCENT; OLIVEIRA CHRYSTELLE; VONGSOUTHI VANIDA; MOREAU FRANCOISE; ESCAICH SONIA 权利人:MUTABILIS SA; DESROY NICOLAS; DENIS ALEXIS; GERUSZ VINCENT; OLIVEIRA CHRYSTELLE; VONGSOUTHI VANIDA; MOREAU FRANCOISE; ESCAICH SONIA 摘要:The invention relates to new 1,2,4-triazine derivatives of formula (I): wherein A, B, R2 and Y are defined in the application, their preparation and intermediates, their use as drugs and pharmaceutical compositions and associations containing them. The compounds of formula (I) are capable of inhibiting bacterial heptose synthesis.
参考标题:An Approach To Spirooxindoles Via Palladium-Catalyzed Remote C-H Activation And Dual Alkylation With Ch2Br2 作者:Changdong Shao,Zhuo Wu,Xiaoming Ji,Bo Zhou,Yanghui Zhang 摘要:A Facile And Efficient Approach For The Synthesis Of Spirooxindoles Has Been Developed Via The Coupling Of Spirocyclic C, C-Palladacycles With Ch2Br2. The Key Spirocyclic Palladacycles Are Generated Catalytically Via Intramolecular Remote C-H Activation. A Range Of Spirooxindoles Can Be Synthesized In Good To Excellent Yields From Readily Available Starting Materials.
合成参考文献
摘要:Irudayanathan, F. M.; Lee, S., Science of Synthesis Knowledge Updates, (2019) 2, 1. 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 280. 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 186. 摘要:Liu, G.; Feng, J., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 325.