CAS: 176486-63-8; (2S,4R)-4-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-1-(Tert-Butoxycarbonyl)Pyrrolidine-2-Carboxylic Acid

相似化合物

1018332-23-4 1018332-24-5 174148-03-9

上下游产品

CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号132622-69-6 (2S,4R)-4-氨基吡咯烷... | CAS号943134-39-2 Danegaptide | CAS号132622-69-6 (2S,4R)-4-氨基吡咯烷...

📜Fluorenylmethyl Succinyl Carbonate,(2S,4R)-1-(Tert-Butoxycarbonyl)-4-Azidoproline Benzyl Ester置于钯 Sodium Carbonate,柠檬酸体系中,用 1,4-二氧六环,甲醇,乙醇,水 用作溶剂,化学反应生成N-叔丁氧羰基-反-4-N-芴甲氧羰基-氨基-L-脯氨酸
参考文献:Novel Peptides As Ns3-Serine Protease Inhibitors Of Hepatitis C Virus
标题:Novel Peptides As Ns3-Serine Protease Inhibitors Of Hepatitis C Virus
摘要:本发明揭示了具有hcv蛋白酶抑制活性的新型肽化合物,以及制备这些化合物的方法.在另一实施方案中,本发明揭示了包含这些肽段的药物组合物,以及使用它们治疗与hcv蛋白酶相关疾病的方法.

专利信息

专利号:US-2010093612-A1
优先权日:2007-02-21
标 题 :Integrin targeted cyclopeptide ligands, their preparation and use
发明人：CASIRAGHI GIOVANNI; BURREDDU PAOLA; MANZONI LEONARDO PIERPAOLO; SCOLASTICO CARLO; ZANARDI FRANCA; BATTISTINI LUCIA; CURTI CLAUDIO; RASSU GLORIA; AUZZAS LUCIANA
权利人:CASIRAGHI GIOVANNI; BURREDDU PAOLA; MANZONI LEONARDO PIERPAOLO; SCOLASTICO CARLO; ZANARDI FRANCA; BATTISTINI LUCIA; CURTI CLAUDIO; RASSU GLORIA; AUZZAS LUCIANA
摘要:The present invention relates to novel hybrid cyclopeptide compounds embodying pyrrolidine- or piperidine-based amino acid substructures grafted onto a RGD (-Arg-Gly-Asp-) tripeptide sequence and acting as targeting ligands towards integrin receptors, intended, for example, for the treatment of altered angiogenic phenomena or for the preparation of therapeutically and/or diagnostically useful compounds; the invention also concerns a process for the synthesis of said cyclopeptides and biologically active derivatives thereof.