CAS: 168072-32-0; 2,4-Dimethylnicotinaldehyde

该化合物是一种多用途的七环甲醚,用作有机合成和制药应用中的关键中间体,其结构以和功能为特点,能够用于制造复杂的分子,包括,催化剂和活性药物成分(APIs).在2和4个位置上存在甲基组,会增强...

英文名称2,4-Dimethylnicotinaldehyde
中文名称2,4-二甲基-3-吡啶甲醛
IUPAC名称2,4-dimethylnicotinaldehyde
其它别名3-Pyridinecarboxaldehyde,2,4-Dimethyl-(9Ci); 2,4-Dimethylpyridine-3-Carboxaldehyde; 2,4-Dimethylnicotinaldehyde; 2,4-Dimethylpyridin-3-Carbaldehyde; 2,4-Dimethyl-3-Pyridinecarboxaldehyde; 2,4-Dimethylpyridine-3-Carbaldehyde; 3-Pyridinecarboxaldehyde, 2,4-Dimethyl-
CAS编号168072-32-0
MFCD编号:MFCD11100698
EINECS号:879-897-3
分子式:C8H9NO分子量:135.17
产品CID: 849588
产品分类医药中间体 → 吡啶类化合物

相似结构搜索
InChIKey: CRDOBBKBXSEULR-UHFFFAOYSA-N
InChI=1S/C8H9NO/c1-6-3-4-9-7(2)8(6)5-10/h3-5H,1-2H3
计算化学: 氢键受体数2.0氢键供体数*可旋转键数1.0

MSDS等安全信息

危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P312-P330-P362-P403+P233-P501-

欧盟法规

C&L通报

上下游产品

(2,4-dimethylpyridin-3-yl)-methanol ethyl 2,4-dimethylnicotinate 2,4-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester [2'-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-yl]-(2,4-dimethyl-pyridin-3-yl)-methanol 4-chloro-N-{5-chloro-2-[(2,4-dimethyl-pyridin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-N-methoxymethyl-3-trifluoromethyl-benzenesulfonamide 3-{Chloro-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-yl]-methyl}-2,4-dimethyl-pyridine 3-[2'-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl]-2,4-dimethyl-pyridine

合成工艺路线路线简述

📜乙基2,4-二甲基吡啶-3-羧化物置于manganese(Iv) Oxide,Lithium Aluminium Tetrahydride体系中,用四氢呋喃,氯仿用作溶剂,化学反应 7.0H,反应生成2,4-二甲基-3-吡啶甲醛
参考文献:非肽血管紧张素ii受体拮抗剂.I.吡啶衍生物的合成和生物活性.
标题:非肽血管紧张素ii受体拮抗剂.I.吡啶衍生物的合成和生物活性.
摘要:取代的吡啶被合成为潜在的血管紧张素ii(aii)受体拮抗剂.在吡啶的2位取代导致有效的活性,并且最佳的烷基长度为四个碳.随着在位置4处引入羟甲基的影响,效力进一步提高.化合物之一是2-丁基-6-氯-4-氯甲基-4-羟甲基-5-甲基-3-[[2'-(1H-四唑-5)-Yl)联苯基-4-Yl]甲基]吡啶9 H(kt3-579)是竞争性aii拮抗剂,Pa2值为9.31,效力是du Pont 753的约10倍.发现它是at1特异性拮抗剂,Ic50为3.09 Nm.
Doi:10.1248/cpb.42.1841