CAS: 167423-93-0; 1-Tert-Butyl 2-Methyl Piperidine-1,2-Dicarboxylate

相似化合物

200184-53-8 18650-38-9 18650-39-0

专利信息

专利号:US-6228872-B1
优先权日:1998-11-12
标 题:Neurotrophic diamide and carbamate agents
发明人：DUBOWCHIK GENE M; DITTA JONATHAN L; PROVENCAL DAVID P; DENHART DEREK J
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel pyrrolidinemethyl diamide and carbamate compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.

专利号:US-6818643-B1
优先权日:1999-12-08
标 题:Neurotrophic bicyclic diamides
发明人：DUBOWCHIK GENE MICHAEL; PROVENCAL DAVID PAUL
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel bicyclic diamide compounds that are neuroprotective and/or neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.